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Category: Volume 06 Issue 02 February 2018
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Title: Diagnostic Outcome of Bone Marrow Aspiration in a Paediatric Centre in Hyderabad, India

Authors: Dr Ather Fatima, Dr Mohd Irshad Ahmed

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.160

Abstract

Introduction: Haematological diseases are common among paediatric age group. They range from common disorders like nutritional deficiency anaemia to very serious and rare conditions like leukemia and syndromic disorders that affecting stem cell differentiation of the bone marrow like Diamond‑Blackfan  syndrome, etc. Bone marrow examination is an important diagnostic tool in haematology. Bone marrow aspiration (BMA) provides reliable information regarding bone marrow cellularity, its architecture and the stage of maturation of different blood cells. It also provides detailed information regarding the presence of haemoparasites within the bone marrow, the presence of infiltrates and storage diseases. It helps in the diagnosis and staging of haematological malignancies.

Objectives

  1. To determine the age and sex distribution of paediatric population.
  2. To identify the common indications for BMA studies in the paediatric population.
  3. To study the pattern of childhood haematological disorders on bone marrow examination.

Materials and Methods: The study was conducted at LOTUS HOSPITALS FOR WOMEN AND CHILDREN, Hyderabad, a specialist referral centre for the children. It is a facility based retrospective cross section study. The data was collected from the hospital records from the Department of Pathology from January 2011 to December 2015.

The data collected include detailed case history with physical examination with all necessary lab investigations. The data was entered into Microsoft excel 2007 version and analysed using Epi info 7.2.1.0

Results: BMA from 220 patients were analyzed. Reactive marrow and Nutritional anemia contributed highest number of cases among the non neoplastic group. Acute lymphoblastic leukemia was the commonest malignant hematological disorder in the present study.

Conclusion: Common haematologic disorders in our setting are reactive marrow, nutritional anaemias and leukaemias. There is need to expand the scope of laboratory investigations beyond morphology.

Keywords: Bone marrow aspiration, indications, outcome.

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Corresponding Author

Dr Ather Fatima

Department of Pathology, Government Medical College, Khaleelwadi, Nizamabad

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