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Category: Volume 06 Issue 02 February 2018
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Title: Prevalence and causes of Anaemia in Children: A Hospital-Based Diagnostic Study

Authors: Rastogi Parag, Sharma Sushil Kumar

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.136

Abstract

Anaemia in children is a major public health problem throughout the world. It is estimated that at least one-third of the population has been at one-time anemic. It is often multifactorial, iron deficiency being the most frequent etiology and reasons like malaria endemicity, poor nutrition including micronutrient deficiency, haemoglobinopathies, frequent bacterial infections and high parasitic infestations have been given for these high prevalence rates. The ranges for Hb were first derived from 554 subjects in whom laboratory values for serum iron/iron-binding capacity, mean corpuscular volume, and erythrocyte protoporphyrin were all normal (≥16%, ≥80 fl, and ≤75 µg/dl red blood cells, respectively). Using these reference standards, the prevalence of Anaemia (Hb values below the 95% reference range for age and sex) among the 354 subjects with complete laboratory results was highest in infants (5.8%), teenage girls (5.10%), young women (5.9%), and elderly men (4.5%). Chronic Anaemia may impair growth, cardiac function and cognitive development in infants but other consequences are rather poorly explored more thoroughly. Chronic disorders and iron deficiency were the most common causes of Anaemia. Anaemia was frequently diagnosed in this series of elderly patients. Partly treatable nutritional deficiencies, such as iron or folate deficiency, were identified as possible causes. A complex and heterogeneous interplay of chronic inflammation, functional iron deficiency, and renal impairment was identified in a large proportion of patients. Measures directed at prevention and control of anemia, include increased coverage of supplementation and fortification programs are strongly recommended.

Keywords: Anaemia, iron-deficiency hemoglobin, prevalence of Anaemia, hemoglobin.

References

  1. Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron metabolism in man. Oxford: Blackwell Scientific Publications, 1979.
  2. Dallman PR, Siimes MA, Stekel A. Iron deficiency in infancy and childhood. Am J Clin Nutr l980;33:86-l 18.
  3. Chalco JP, Huicho L, Alamo C, Carreazo NY, Bada CA. Accuracy of clinical pallor in the diagnosis of anaemia in children: a meta-analysis. BMC Pediatr. 2005; 5:46.
  4. Kalantri A, Karambelkar M, Joshi R, Kalantri S, Jajoo U. Accuracy and reliability of pallor for detecting anaemia: a hospital-based diagnostic accuracy study. PLoS One. 2010;5 (1):8545.
  5. Dallman PR. Manifestations of iron deficiency. Semin Hematol 1982;l9:l9-30.
  1. FAO, WHO. World declaration and plan of action for nutrition: Food and Agriculture Organization of the United Nations; 1992.
  2. Ferinject. Summary of Product Characteristics www.medicines.org.uk Accessed February 6th 011.
  3. Lyseng-Williamson KA, Keating GM. Ferric carboxymaltose: a review of its use in iron-deficiency Anaemia. Drugs. 2009: 69:739–756.
  4. Garby L, Irnell L, Werner I. Iron deficiency in women of fertile age in a Swedish community. III. Estimation ofthe iron status ofa population. Acts MedScand l969; l85:ll3-l7.
  5. Iron deficiency in the United States. Committee on iron deficiency. JAMA 1968; 203:407-l2.
  6. Joosten E, Pelemans W, Hiele M, Noyen J, Verhaeghe R, Boogaerts MA. Prevalence and causes of anaemia in a geriatric hospitalized population. Gerontology. 1992; 38:111–7.
  7. Ludwig H, Müldür E, Endler G, Hübl W. Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and Anaemia. Ann Oncol. 2013; 24 (7) :1886–1892.
  8. Aapro M, Osterborg A, Gascon P, et al. Prevalence and management of cancer-related anaemia, iron defciency and the specifc role of i.v. iron. Ann Oncol. 2012;23(8):1954–1962.
  9. Meyers LD, Habicht J-P, Johnson CL. Components of the difference in hemo-globin concentrations in blood between black and white women in the United States. Am J Epidemiol 1979;109:539-49.
  10. Monofer. Summary of Product Characteristics www.medicines.org.uk Accessed February 6th 2011
  11. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M. Heart disease and stroke statistics-2015 update: a report from the American heart association. Circulation. 2015;131 (4):29.
  12. National Center for Health Statistics. Singer JD, Granahan P, Goodrich NN, Meyers LD, Johnson CL. Diet and iron status, a study of relationships: United States, 1971-74. Vital and health statistics. Series II, no 229. DHHS publication no (PHS) 83- 1679. Public Health Service. Washington, DC: US Government Printing Office, December 1982:36-7.
  13. Lipschitz DA, Mitchell CO. Thompson C. The Anaemia of senescence. Am J Hematol l981;l 1:47-54
  14. Osei-Bimpong A, McLean R, Bhonda E, Lewis S. The use of the white cell count and haemoglobin in combination as an effective screen to predict the normality of the full blood count. International Journal of Laboratory Haematology. 2012; 34 (1): 91-97.
  15. Hong YJ, Jeong MH, Choi YH, Song JA, Kim DH, Lee KH. Relation between anaemia and vulnerable coronary plaque components in patients with acute coronary syndrome: virtual histology-intravascular ultrasound analysis. Journal of Korean Medical Science. 2012; 27(4):370-76
  16. Merono O, Cladellas M, Recasens L, Garcia-Garcia C, Ribas N, Bazan V. Inhospital acquired Anaemia in acute coronary syndrome. Predictors, in-hospital prognosis and one-year mortality. Revista Española de Cardiología (English Edition). 2012; 65(8):742-48
  17. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK. Diagnosis and management of iron deficiency Anaemia: a clinical update. Med J Aust. 2010;193 (9):525-32.
  18. Laxmaiah A, Rao M, Kumar RH, Arlappa N, Venkaiah K, Brahmam G. Diet and nutritional status of tribal population in ITDA project areas of Khammam district, Andhra Pradesh. J Hum Ecol. 2007;21 (2): 79-86.
  19. Mozos I. Mechanisms linking red blood cell disorders and cardiovascular diseases. BioMed Research International. 2015.
  20. Moura B. Anaemia and prognosis in acute coronary syndromes. Revista Portuguesa de Cardiologia (English Edition). 2012; 31(2):133-34.
  21. Pedersen AN, Fagt S, Groth MV, Christensen T, Biltoft-Jensen, Matthiessen J. Dietary habits in Denmark 2003–2008. Main results: National Food Agency of Denmark. 2010.
  22. Krafft A, Breymann C. Iron sucrose with and without recombinant erythropoietin for the treatment of severe postpartum Anaemia: a prospective, randomized, open-label study. J Obstet Gynaecol Res.2011; 37:119–124
  23. Ten-state nutrition survey 1968-70. IV. Biochemical DHEW publication no (HSM) 72-8132. Atlanta, GA: US Department of Health, Education, and Welfare, Centers for Disease Control, 1972.
  24. Teunissen M, Hijmans CT, Cnossen MH, Bronner MB, Grootenhuis MA, Peters M.  Quality of life and behavioral functioning in Dutch pediatric patients with hereditary spherocytosis. Eur J Pediatr. 2014; 173(9):1217–1223.
  25. Trygg K, Lund-Larsen K, Sandstad B, Hoffman HJ, Jacobsen G, Bakketeig LS Do pregnant smokers eat differently from pregnant non-smokers? Paediatr Perinat Epidemiol. 1995; 9:307–319. Nordic Council of Ministers. Nordic Nutrition Recommendations 2004. Copenhagen 2004
  26. Wang W, Bourgeois T, Klima J, Berlan ED, Fischer AN, O'Brien SH.. Iron deficiency and fatigue in adolescent females with heavy menstrual bleeding. Haemophilia. 2013;19 (2):225–230.
  27. Panepinto JA, Torres S, Bendo CB, McCavit TL, Dinu B, Sherman-Bien S, Bemrich-Stolz C, Varni JW. PedsQL Multidimensional Fatigue Scale in sickle cell disease: feasibility, reliability, and validity. Pediatr Blood Cancer. 2014;61 (1):171–177.
  28. Gv S, Pk S, Herur A, Chinagudi S, Patil SS, Ankad RB, Badami SV. Correlation between haemoglobin level and electrocardiographic (ECG) findings in anaemia: a cross-sectional study. J Clin Diagn Res. 2014;8 (4):BC04–06
  29. WHO, UNICEF, UNU. Iron defciency anaemia: assessment, prevention and control, a guide for programme managers. Geneva: World Health Organization. 2001
  30. Wonke B. Bone disease in beta-thalassaemia major. Br J Haematol. 1998;103 (4):897–901
  31. World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Geneva, Switzerland: World Health Organization; 2011. Available from: http://www.who. int/vmnis/indicators/haemoglobin.pdf. Accessed May 5, 2014.
  32. Zamboni V, Cesari M, Zuccalà G, Onder G, Woodman RC, Maraldi C, Ranzini M, Volpato S, Pahor M, Bernabei R.. Anaemia and cognitive performance in hospitalized older patients: results from the GIFA study. Int J Geriatr Psychiatry. 2006; 21:529–34.
  33. Beghe C, Wilson A, Ershler WB. Prevalence and outcomes of Anaemia in geriatrics: a systematic review of the literature. Am J Med. 2004;116 (7):3S–10.

Corresponding Author

Dr Sushil Kumar Sharma

Assist. Prof, Department of Physiology, VIMS Gajrola (UP) India

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