Title: Influence of Gender on Cardiac Autonomic Reactivity in Young Adults

Authors: Dr Nadeema Rafiq, Dr Tauseef Nabi, Dr Shaugfta Aara, Dr Qurat –Ul-Ain-Arifa

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.124

Abstract

Our cardiovascular system is governed by autonomic nervous system. Since adults have lower cardiovascular risk, this study is aimed to find out gender differences in cardiac autonomic nervous activity by assessing various non-invasive tests like Lying to Standing test, Valsalva maneuver, sustained Hand grip test (HGT) and Cold pressor test (CPT). Study was done in healthy males and females ranging in age from 18 to 25 years. The mean basal systolic blood (SBP) pressure of males was significantly highly raised than females The mean SBP before and after HGT as well as CPT was higher for males than females and the difference was highly significant (P < 0.001). This study suggests, heart rate response to Standing and Heart rate changes during the Valsalva manoeuvre (Valsalva Ratio), denoting vagal activity, were not significantly different between males and females, whereas the SBP was more marked for males than females both before and after the stressors reflecting a higher sympathetic activity in males compared to females.

Keywords:  Autonomic nervous system, vagal activity, sympathetic activity, gender, hand grip test, cold pressure test.

References

  1. Rosenwinkel ET, Bloomfield DM, Arwady MA, Goldsmith RL. Exercise and autonomic function in health and cardiovascular disease. Cardiology Clinics. 2001; 19(3):369-87.
  2. Xiao-Ju D and Kingwell BA. Gender, sex hormones and autonomic nervous control of cardiovascular system. Oxford Journal. 2002; 53(3): 678-87.
  3. R Gupta, P Joshi, V Mohan, K S Reddy, S Yusuf. Epidemiology and causation of coronary heart disease and stroke in India. Heart. 2008;94:16-26.
  4. Huxley VH. Sex and the cardiovascular system: the intriguing tale of  how women and men regulate cardiovascular function differently. Adv Physiol Educ 2007; 31(1):17-22.
  5. Jane F. Reckelhoff. Gender Differences in the Regulation of Blood Pressure. Hypertension. 2001;37:1199-1208
  6. Moodithaya S, Avadhany S. Gender differences in age-related changes in cardiac autonomic nervous function. J Aging Res. 2012;2012:679345.
  7. Kuo TBJ, Lin T, Yang CCH, Li CL, Chen CF, Chou P. Effect of aging on gender differences in neural control of heart rate. American Journal of Physiology. 1999;277 (6):2233-9.
  8. Geelen G, Laitinen T, Hartikainen J, et al. Gender influence on vasoactive hormones at rest and during a 70 degree head-up tilt in healthy humans. J Appl Physiol. 2002;92(4):1401-8.
  9. T. Yukishita, K. Lee, S. Kimet al. Age and sex dependent altertations in heart rate variability; profiling the characteristics of men and women in their 30. Journal of Anti-Aging Medicine. 2010;7( 8): 94–9.
  10. Khandelwal E, Jaryal AK, Deepak KK. Cardiovascular autonomic functions & cerebral auto regulation in patients with orthostatic hypotension. Indian J Med Res. 2011; 134(4): 463-9.
  11. Deepak D, Sinha AN, Gusain VS, Goel A. A study on effect of meditation on sympathetic nervous system functional status in meditators. Journal of Clinical & Diagnostic Research. 2012; 6(6): 938-42.
  12. Reckelhoff JF. Gender differences in the regulation of blood pressure. Hypertension. 2001;37:1199-208.
  13. Lash SJ, Gillespie BL, Eisler RM, Southard DR. Sex differences in cardiovascular reactivity: effects of the gender relevance of the stressor. Health Psychol 1991;10:392–98.
  14. Stoney CM, Davis MC, Matthews KA. Sex differences in physiologyical responses to stress and in coronary heart disease: a causal link. Psychophysiology. 1987; 24: 127–31.
  15. Light KC, Turner JR, Hinderliter AL, Sherwood A. Race and gender comparisons, Hemodynamic responses to a series of stressors. Health Psychol. 1993; 12: 354–65
  16. Schondorf R, Low PA. Gender related differences in the cardiovascular responses to upright tilt in normal subjects. Clin Auton Res. 1992; 2: 183–87.
  17. Madden K, Savard GK. Effects of mental state on heart rate and blood pressure variability in men and women. Clin Physiol 1995; 15:557–69.
  18. Yamasaki Y, Kodama M, Matsuhisa M et al. Diurnal heart rate variability in healthy subjects: effects of aging and sex difference. Am J Physiol 1996;271:303–10.
  19. D. Ramaekers, H. Ector, A. E. Aubert, A. Rubens, F. Van De Werf. Heart rate variability and heart rate in healthy volunteers: is the female autonomic nervous system cardioprotective?. European Heart Journal, 1998.19;( 9):1334-41
  20.  Larsen JA, Kadish AH. Effects of gender on cardiac arrhythmias. J Cardiovasc Electrophysiol. 1998;9(6):655-64.
  21. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, et al. Heart disease and stroke statistics—2006 update: a report from the American Heart Assoc-iation Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006;113(6):85-151.
  22. Benjamin IJ, Christians E. Exercise, estrogen, and ischemic cardioprotection by heat shock protein 70. Circ Res. 2002;90 (8):833-5.
  23.  Minson CT, Halliwill JR, Young TM, Joyner MJ. Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation. 2000;101 (8):862-8.
  24. Saleh TM, Connell BJ. Estrogen-induced autonomic effects are mediated by NMDA and GABAA receptors in the parabrachial nucleus. Brain Res. 2003; 973(2):161–70.
  25.  Mohamed MK, El-Mas MM, Abdel-Rahman AA. Estrogen enhancement of baroreflex sensitivity is centrally mediated. Am J Physiol. 1999;276(4):1030-7.
  26. X. J.Du, A. M. Dart, and R. A. Riemersma. Sex differences in the parasympathetic nerve control of rat heart. Clinical and Experimental Pharmacology and Physiology. 1994;21(6):485-493.
  27. Hermann M, Flammer A, Luscher TF. Nitric oxide in hypertension. J Clin Hypertens. 2006;8(12):17-29.
  28. Klahr S. The role of nitric oxide in hypertension and renal disease progression. Nephrol Dial Transplant. 2001;16(1):60-2.
  29. Eaker ED, Packard B, Thom TJ. Epidemiology and risk factors for coronary heart disease in women. Cardiovasc Clin. 1989;19:129-45.

Corresponding Author

Dr Tauseef Nabi

Address: 6-School Enclave, Rawalpora, Srinagar, J&K.190005 India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.