Title: Misoprostol for Induction of Labor: A Review

Authors: Mahajan M, Gupta, KB, Sharma, R

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.120

Abstract

Induction of labor is widely used across the globe in cases where continuing pregnancy is unsafe for the mother and/or her fetus. Numerous techniques are available for induction of labor. Use of misoprostol appears one of the effective methods of cervical ripening and labor induction. The effectiveness and safety of misoprostol administered vaginally or orally for labor induction have been reviewed in the present paper. Since the use of misoprostol can have maternal and perinatal implications, it is important to review the effectiveness of misoprostol in cervical priming and induction of labor. This paper reviews the effectiveness and safety of misoprostol administered orally, sublingually and vaginally for induction of labor.

Keywords:  Induction of labor, Misoprostol, oral administration, vaginal, sublingual

References

  1. Steven G. Gabbe, Jennifer R. Niebyl and Joe Leigh Simpson. Normal and problem pregnancies. 373; 4th
  2. Norman M, Ekman G and MalmstormA Prostaglandin E2 – Induced ripening of the human cervix involves changes in prosteoglycan metabolism. Gynecol. 1993; 82:1013-20.
  3. Sanchez- Ramos L, Kaunitz AN, Del Valle GO et al. Labor induction with prostaglandin E1 methyl analogmisoprostal vs. oxytocin: A randomized trial. Gynecol. 1993: 81: 332-336.
  4. Sherbiny MTE, Gharieb IHEL, Gewely HA. Vaginal misoprostol for induction of labor: 25 vs. 50 µg dose regimen. International Journal of Gynaecology and Obstetrics. 2001; 72:25-30.
  5. Karim SMM and Sharma SD. Therapeutic Abortion and Induction of Labor by the Intravaginal Administration of Prostaglandins. The Journal of Obs. and Gyn. of the Brit. Cwlth. 1971; 78:294-300.
  6. Nelson GH and Bryans CI. A comparison of oral prostaglandins E2 and intravenous oxytocin for induction of labor in normal and high risk pregnancies. Am J Obstet& Gynecol1976; 126(5):549-554.
  7. Rajan R, Kumari A and Molykutty T. Elective Induction of labor by forewater amniotomy. Journal of obs. and gyn. ogind. 1983:33(6); 760-65.
  8. Johnson IR, Macpherson, Welch CC and Filshie GM. A Comparison of Lamycel and Prostaglandin E2 Vaginal gel for cervical ripening before induction of labor. Am J Obstet Gynecol1985; 151(5):604-7.
  9. Hamilton BE, Martin JA, Ventura SJ. Births: preliminary data for 2012. Natl Vital Stat Rep. 2013; 62(3):1–20.
  10. Gemzell-Danielsson K, Marions L, Rodriguez A, et al.Comparison between oral and vaginal administration of misoprostol on uterine contractility. Obstet Gynaecol, 1999; 93: 275 -280
  11. US food and Drug Administration. Full revised misoprostol (Cyto-tec) label – Searle. 2002. Available from: www.accessdata.fda.gov/drugsatfda_docs/label/2002/19268slr037.pdf. Accessed November18, 2014.
  12. Fletcher HM. Intravaginal Misoprostol as a Cervical Ripening Agent. BJOG 1993; 100:641-44.
  13. Beigi A, Kabiri M and Zarrinkoub F. Cervical ripening with oral misoprostol at term. International journal of Gynaecology and Obstetrics 2003; 83:251-255.
  14. Ramsey PS, Harris DY, Ogburn PL Jr, Heise RH, Magtibay PM, Ramdin KD. Division of maternal-fetal medicine. Am J ObstetGynecol 2003; 188(2):560-5.
  15. Langenegger EJ, Grove OD. Oral misopr-ostol verses intracervical dinoprostone for induction of labor. International journal of Gynaecology and Obstetrics 2005; 88:242-248.
  16. Wing DA, Jones MM, Rahall A, Goodwin TM, Paul RH. A comparison of misoprostol and prostaglandin E2 gel for pre-induction cervical ripening and labor induction. Am J Obstet&Gynecol 1995; 172(6):1804-10.
  17. Danielian P, Porter B, Ferri N, Summers J and Templeton A. Misoprostol for induction of labor at term: A more effective agent than dinoprostone vaginal gel. British Journal of Obstetrics and Gynecology. 1999; 106:793-797.
  18. Bartha JL, Comino-Delgado R, Garcia-Benasach F, Martinez-Del-Fresno P, Moreno-Corral LJ. Oral misoprostol and intracervical dinoprostone for cervical ripening and labor induction: A randomized comparison. Gyneco. 2000; 96(3):465-469.
  19. Gemund VN, Scherjon S, Cessie S le, Leeuwen JHS, Roosmalen JV and Kanhai HHH. A randomized trial comparing low dose vaginal misoprostol and dinoprostone for labor induction. Br J ObstetGynaecol 2004; 111:42–49.
  20. Shetty A, Livingstone I, Rice P, Acharya S, Danielian P and Templeton A. A randomized comparison of oral misoprostol and vaginal prostaglandin E2 tablets in labor induction at term. International journal of Obstetrics and Gynaecology. 2004; 111:436-440.
  21. Baruah J, Das GC and Roy KK. A comparison between intravaginal misoprostol and intra-cervical PGE2 for induction of labor – A clinical study in Indian women. International Journal of Gynecology and Obstetrics India 2005; 8(5):57-61.
  22. Mahajan M, Gupta KB, Sharma, R and Dogra P Comparative study of induction of labor by sublingual misoprostol with dinoprostone gel. Journal of Paediatrics, Obstetrics & Gynaecology 2010; 1(7):272-76.
  23. Roux PA le, Olarogun JO, Penny J and Anthony J. Oral and vaginal misoprostol compared with dinoprostone for induction of labor: A randomized controlled trial. Obstetrics & Gynecology. 2002; 81(2):201-04.
  24. Garlan SJ, Blust D and O’Brien W. Safety and efficacy of Misoprostol orally and vaginally: A randomized trial. Obstetrics and Gynaecology. 2001; 98(1):107-112.
  25. Ramos LS, Kaunitz M and Delke I. Labor induction with 25 micrograms verses 50 micrograms intravaginal misoprostol: A systematic review. Obstetrics and Gynaecology. 2002; 99(1):145-151.
  26. Bartusevicius A, Barcaite E and Nadisauskiene R. Oral, vaginal and sublingual misoprostol for induction of labor. International Journal of Gynaecology and Obstetrics 2005; 91:2-9.
  27. Lokugamage AU, Forsyth SF, Sullivan KR, Refaey HE and Rodeck CH. Dinoprostrone verses misoprostol: A randomized study of nulliparous women undergoing induction of labor. Obstet. Gynecol. Scand. 2003; 82:133-137.
  28. Wing DA, Ham D and Paul RH. A comparison of orally administered misoprostol with vaginally administered misoprostol for cervical ripening and labor induction. Am J Obstel& Gynecol. 1999; 180(5):1155-60.
  29. Wing DA, Park MR and Paul RH. A randomized comparison of oral and intravaginal misoprostol for labor induction. Obstet Gynecol. 2000; 95(6):905-08.
  30. Bartusevicius A, Barcaite E, Krikstolaitis R, Gintautas V and Nadisauskiene R. Sublingual compared with vaginal misoprostol for labor induction at term: A randomized controlled trial. BJOG 2006; 113:1431-1437.
  31. Feitosa FEL, Sampalo ZS, Alencar CA, Amori MMR, Passini R. Sublingual versus vaginal misoprostol for induction of labor. International journal of Gynaecology and Obstetrics 2006; 94:1012-1021.
  32. Shetty A, Martin R, Danielian P and Templeton A. A comparison of two dosage regimens of oral misoprostrol for labor induction at term. ActaobstetGynecol Scand. 2002; 81:337-342.
  33. Shetty A, Danielian P and Templeton A. Sublingual misoprostol for induction of labor at term. Am J ObstetGynecol 2002; 186(1):72-76.
  34. Casterneda CS, Puente JCI, Ochoa RALO, Plasse TF, Powers BL and Rayburn WF. Misoprostol dose selection in a controlled-release vaginal insert for induction of labor in nulliparous women. Am J ObstetGynecol2005; 193:1071-1075.
  35. Stephenson ML, Powers BL, Wing DA. Fetal heart rate and cardiotoco­graphic abnormalities with varying dose misoprostol vaginal inserts. J MaternFetal Neonatal Med. 2013; 26(2):127–131.
  36. Wing DA, Brown R, Plante LA, Miller H, Rugarn O, Powers BL. Misoprostol vaginal insert and time to vaginal delivery: A randomized controlled trial. Obstet Gynecol. 2013; 122(2 Pt 1):201–209.
  37. Souza ASR, Feitosa FEL and Costa, AAR Titrated oral misoprostol solution versus vaginal misoprostol for labour induction. International Journal of Gynaecology Obstetrics India Volume 16 No.:6, 432-437.
  38. Deshmukh VL, Aporva V and Ylelikar RKA Oral Misoprostol solution for induction of labor. The Journal of Obstetrics and Gynaecology of India 2017; 67 (2):98-103.
  39. Plaut MM, Schwartz ML and Lubarsky SL. Am J Obstet&Gynecol 1999; 180(6):1535-42.
  40. Majoko F, Magwali T, Zwizwai M Uterine rupture associated with use of misoprostol for induction of labor. International journal of gynaecology and obstetrics. 2002; 76:77-78.
  41. Hofmeyr GJ, Gulmezoglu AM Vaginal misoprostol for cervical ripening and induction of labor in late pregnancy. The Cochrane Library, 2001:2

Corresponding Author

Mahajan M

M.S. (OBG) Government Civil Hospital, Theog, District Shimla, Himachal Pradesh

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