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Category: Volume 06 Issue 02 February 2018
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Title: Effects of Different Antioxidants on Sperm Parameters in Infertile Males

Authors: Mohamed Abdel Moaty El Samra, Sherif Mansour Aggag

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.117

Abstract

Infertility is one of the most serious social problems facing all communities. The aim of this randomized controlled study is to assess the effect of certain antioxidants on the semen parameters. 105 infertile males aged between 20 and 40 years with oligoasthenoteratospermia from the Infertility Clinic in Shatby University Hospital were subjected to routine investigations, Computer Assisted Semen Analysis (CASA) and scrotal ultrasonography. They were allocated to 3 groups (35 males each); first group received vitamin C 1000 mg and zinc 20 mg, second group received Acetyl cysteine 200 mg and selenium 100 µg, and third group received vitamin E 1000 mg and folic acid 400 µg, once daily for 12 weeks. Sperm concentration among the three studied groups before and after treatment was not statistically significantly different (p=0.682, 0.500; respectively). Sperm motility increased after treatment in the three studied groups (p=0.000). Normal forms of sperms increased after treatment when compared with before treatment in the three studied groups (p=0.000). Combination of oral antioxidant therapy is important for the improvement of one or more of sperm parameters in infertile male with oligoasthenoteratozoospermia. This study suggests that N-Acetyle-Cysteine and selenium are the appropriate antioxidant combination but future studies should be done on wider scale of antioxidants to choose the best to serve humanity.

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Corresponding Author

Mohamed Abd El-Moety El-Samra

Address: 175 elhorreya street, Alexandria, Egypt

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