Title: Spectrum of Colorectal Cancers in a Tertiary Care Centre-A Clinico-Pathological Correlation
Authors: Dr P.S.Mulay, Dr Soundararajan Rama, Dr S.A.Deshpande, Dr M.M.Mattawar
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.99
Abstract
Introduction: Large intestine is affected by various types of lesions, both non-neoplastic and neoplastic. Due to vague symptoms, the clinical diagnosis is usually delayed. Colorectal cancer is the third leading cancer worldwide, accounting for approximately 9% of all cancers. A set of laboratory tests including biopsy is essential to arrive at a specific diagnosis for appropriate management.
Aims and Objectives: The aim of this study is to find out the site wise distribution of colorectal tumours and to study the clinical profile and histopathology of various lesions.
Materials and Methods: This two years study was done in Department of Pathology, Dr SCGMC Nanded from 2015-2017 which included biopsies and resected specimens of large intestine and Anal canal. All tissues were fixed in formalin, stained with H&E and special stains like Periodic Acid Schiff (PAS), Reticulin, Zeihl Neelsen (ZN) were done as and when required.
Results: Out of 37 malignant lesions, 13 cases(35.0%) were Well differentiated Adenocarcinomas, 10 cases (27.1%)were Moderately differentiated Adenocarcinomas, 01 case (02.7%) was Poorly differentiated, 05 cases (13.6%) were Mucin secreting Adenocarcinomas and 01 case(02.7%) was Signet ring cell carcinoma. The most common histological grade in the present study was well differentiated Adenocarcinoma.
Conclusion: Adenocarcinomas are the most common malignant lesions of colon in our study. As there is increasing incidence of malignancies early diagnosis by endoscopic biopsies in clinically suspicious patients is recommended for good management.
Keywords: Adenocarcinoma, Colon, Rectum, Histopathology, Malignant lesion.
References
- Liu C, Crawford JM. The Gastrointestinal tract. In: Kumar, Abbas, Fausto, editors. [1]Robbins and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia. Saunders; 2004. Pp.797-876.
- Shike M, Winawer SJ, et al. Primary Prevention of colorectal cancer. The WHO collaborating Center for the Prevention of Colorectal Cancer. Bull World Health Organ. 1990; 68(3):377-385.
- Mandal BK, Schofield PF, Morson BC. A clinicopathological study of acute colitis: the dilemma of transient colitis syndrome. Scand J Gastroenterol. 1982;17(7):865-69.
- Rajbhandari M, Karmacharya A, Khamal K, Dhakal P, Shreshtha R. Histomorpho-logical profile of colonoscopic biopsies and pattern of colorectal carcinomas in Kavre district. Kathmandu Univ Med J 2013; 43(3):196-200.
- Fenoglio-Preiser CM, Noffsinger AE, Stemmerman GN, Lantz PE, Isaacon PG. Gastrointestinal pathology An Atlas and Text. 3rd ed. Philadelphia: Lippincot Williams & Wilkins; 2008. Chapter 14, Epithelial neoplasms of the colon; pp.899- 1036.
- Laishram RS, Kaiho N, Shimray R, Devi SB, Punyabati P, Sharma DC. Histopathological evaluation of colorectal carcinomas status in Manipur, India. Int J Pathol 2010;8:5-8.
- Chaitanya B, Ramakrishna BA, Shanthi V, Reddy S. Microscopy After Colonoscopy: An Institutional Experience In India. Int J Med Res Rev 2014;2:92-97.
- Shah A, Wani NA. A study of colorectal adenocarcinoma. Indian J Gastroenterol 1991;10:12-3.
- Mc Swain B, Sadler RN, Main FB. Carcinoma of the colon, rectum and anus. Ann Surg 1962;155(5):782-794
- Falterman KW,Hill CB,Markey JC, Fox JW, Cohn I. Cancer of the colon,rectum and anus: A review of 2,313 cases.Cancer 1974;34:951-9
- Ahmad Z, Idrees R, Ahmed R,Kalyani N, Pervez S, Hasan SH. Colorectal carcinoma, extent and spread in our population. Resection specimens give valuable information. J Pak Med Assoc 2005;55(11):483-5