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Category: Volume 06 Issue 02 February 2018
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Title: Incidence of Adverse Drug Reactions in a South Indian Tertiary Care Hospital

Authors: Yella Dinesh, MK.Misbahuddin, Syed Akheel Ahmed

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.98

Abstract

The World Health Organization defines an adverse drug reaction (ADR) as “a response to a drug which is noxious and unintended, and which occurs at doses normally used in man for the prophylaxis, diagnosis, or therapy of disease, or for the modification of physiological function.” The fact that drugs might have effects on humans other than the ones intended has been known for many years. During the six month study period, a total 232 patients visited the tertiary care hospital and Celestee skin and hair Clinic. Highest number of patients were from the age group of 21-30 i.e. 33.81%. Majority of the ADRs were from the drug class antibiotics 24 (25.35%). According to Naranjo’s causality assessment scale, out of 71 ADRs the dechallenge was done in all cases, out of which 45 cases (63.3%) were probable and 14 cases (19.7%) were possible where as remaining 12 cases (16.9%) were in unlikely category. We also assessed the severity by using Hartwig and Siegel severity assessment scale; it shows that highest number of cases i.e.,42 (59.15%) fall into moderate type and 10 cases(14.08%) were mild type whereas 19cases (26.76%) fall into severe ADRs.

Keywords: Adverse drug reactions, Pharmacovigilance.

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Corresponding Author

MK.Misbahuddin

Pharm-D, Bhaskar Pharmacy College, Yenkapally Village,

Moinabad, Hyderabad, Telangana, India