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Category: Volume 06 Issue 02 February 2018
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Title: Beta-Catenin Expression in Gallbladder Tissues and Its Role in Carcinogenesis and Tumor Progression in Gallbladder Carcinoma

Authors: Dr Chandrawati, Dr Santosh Kumar, Dr Shaila Mitra

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.92

Abstract

Background: Gallbladder carcinoma is the most common malignancy in the biliary tract, the fifth commonest cancer of the gastrointestinal tract. Oncogenes (beta-catenin) has been shown to be involved in the development and progression of gallbladder carcinoma. The present study has been conducted with an aim to study the expression patterns of beta-catenin in different gallbladder tissues to elucidate the role of this oncogene in carcinogenesis and to evaluate its relationship with tumor progression.

Materials and Methods:  The study was conducted on histological sections from surgically resected 112 specimens of gallbladder tissue lesions operated at the Department of Surgery, Nehru Chikitsalaya, Gorakhpur which included 66 cases of chronic cholecystitis, 34 cases of gallbladder carcinoma and 12 specimens of gallbladder controls as part of other surgical procedures with no pathology in the gall bladder.

Results: Beta-catenin nuclear expression in gallbladder cancer was significantly higher than in chronic cholecystitis and normal gallbladders (P < 0.0001). With increasing (T) depth of tumor invasion (P = 0.0231) and stage of the lesions (p= 0.0226), there is also an increase in the nuclear expression of beta-catenin. The level of beta-catenin expression increased from 44.44% in well differentiated (low grade) to 100% in poorly differentiated (high grade) tumor (P = 0.0463).Thus suggesting a role in tumor progression.

Conclusion: In present study, it was observed that expression of beta‑catenin get altered in gallbladder carcinoma and has a significant role in carcinogenesis and progression of gallbladder carcinoma.

Keywords: Gallbladder carcinoma, Beta-catenin, “T”- depth of tumor invasion, stage of the lesion.

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Corresponding Author

Dr Chandrawati

B.R.D.M.C. Gorakhpur