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Category: Volume 06 Issue 02 February 2018
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Title: Role of Circulating C Reactive Protein in Thyroid Disorders

Authors: Naved Ahmad, Prof. Suryakant Nagtilak, Prof Anil Kumar Sharma M.D, Prof Pawan Parashar M.D, Assoc. Prof Amit Rastogi M.D, D.M (Endocrinology)

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.77

Abstract

Introduction: High sensitive C– reactive protein (hs-CRP) is an important sensitive inflammatory marker. Serum level of hs-CRP is not a routine investigation parameter to diagnose thyroid disorders, although many thyroid conditions involve inflammation. In the present study, the level of the hs-CRP and its association with thyroid disorders were assessed.

Material & Methods: A total of 91 males and 111 females, from the age group of 20 to 55 year were selected for the study. Estimation of hs-CRP was done on semi auto analyzer (Robonikread well touch ) by Enzyme immunoassay technique, the serum was also assayed for T3, T4 & TSH by enzyme linked florescent assay ( ELFA) technique using Vidas auto –analyzer.

Result: In our study we have found the Value of T3 in cases is 1.13± 0.88 nmol/L is high as compared to control group value 1.04± 0.28 nmol/L, Value of T4 in cases is 90.64 ±59.87 nmol/L as compared to control group value 92.47± 12.91 nmol/L, Values of TSH in cases is 7.15± 6.58 mIU/L is very high as compared to control group value 2.27 ±1.06 mIU/L. During our study we have also found values of hs CRP in cases 2.86± 0.97 mg/L as compared to control 1.89 ±0.62 mg/L

Conclusion: Our study findings suggest that abnormal thyroid hormones level interfere with the serum levels of hs–CRP which can have the implications related to Cardio vascular diseases.

Keywords: T3,T4,TSH, hsCRP & Thyroid Disorders.

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Corresponding Author

Prof. Suryakant Nagtilak

Professor and Head Department of Biochemistry,

Shri Dev Suman Subharti Medical College, Dehradun, Uttarakhand, India

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