Title: Prevalence of Subclinical hypothyroidism in females of Jammu region
Authors: Dr Sanjeev Kumar, Dr Ashima Badyal
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.76
Abstract
Subclinical thyroid disease is defined biochemically by an abnormal thyrotropin (TSH) level and normal serum –free thyroxine level. The prevalence of this condition varies according to the reference range for TSH and geographic or demographic factors. Whereas iodine rich diet is necessary for proper thyroid gland function substantial numbers of patients have risk of SCH getting converted into primary hypothyroidism and subclinical hypothyroidism is associated with serious complications. The iodine intake is inversely correlated with thyroid function; deficient iodine intake is related with hyperthyroid status while excessive or sufficient intake of iodine is associated with hypothyroidism.
This study was conducted on 500 people attending the OPD in the Department of Medicine in collaboration with Department of Medicine, at Government Medical College Jammu from January 2017-March 2017. Out of the total, only 102 (20.4%) cases had SCH, with females comprising the majority (79.4%). Patients with TSH >4.3 mIU/ml and T3 and T4 in normal reference range are considered suffering from subclinical hypothyroidism (SCH).
The result clearly reflects the incidence of SCH amongst the demography of the region showing prevalence amongst the elderly and women. Despite all these known facts women still continue to suffer. Subclinical hypothyroidism affects 3-15% of adult population. Its clinical and biochemical profile not well defined, especially in Indian scenario.
Keywords: Subclinical hypothyroidism, thyroid stimulating hormone, Iodine.
References
- Gunter EW, Spencer CA, Braverman LE. Serum TSH, T4 and Thyroid antibodies in the United States population: National Health and nutrition examination survey. J Clin Endocrinol Metab 2002; 87: 489-99.
- Gibbons V, Lills S. Conaglen JV, Lawrenson R. Do general practitioners use thyroid stimulating hormone assay for opportunistic screening. N z Med J 2009; 12: 25-30.
- Bell RJ, Rivera-woll L, Davison SL, Topliss DJ. Well being, health related quality of life and cardiovascular disease risk profile in women with subclinical thyroid disease: a women with subclinical thyroid disease: a community based study. Clin Endocrinol 2007; 66: 548-56.
- Boekholdt SM, Titan SM, Weirsinga WM, Chatterjee K, et al. Initial thyroid status and cardiovascular risk factors: the EPIC –Norfolk prospective population study. Clin Endocrinol 2010; 72: 404-10.
- Iervasi G, Molinaro S, Landi P, Taddei MC, Galli Eet al. Association between increased mortality and thyroid dysfunction in cardiac patients. Arch Intern Med 2007; 167: 1526-32.
- Sgarbi JA, Villaca FG, Garbeline B, Villar HE, et al. The effects of early anti-thyroid therapy for endogenous subclinical hypothyroidism in clinical and heart abnormalities. J Clin Endocrinol Metab 2003; 88: 1672-7.
- Faber J, Jensen IW, Peterson L, Nygaard B, et al. Normalization of serum thyrotropin by means of radioiodine treatment in subclinical hyperthyroidism: effect on bone loss in post menopausal women. Clin Endocrinol 1998; 48: 285-90.
- Imaizumi M, Sera N, Horie I, Ando T, et al. Risk for progression to overt hypothyroidism in an elderly Japanese population with subclinical hypothyr-oidism. Thyroid 2011; 21: 1177-82.
- Rafiq M. Prevalence survey of iodine deficiency disorder in 8-10 years old school children and use of iodized salt, Swat District NWFP report 1998.
- Triggiani V, Tafaro E, Giagulli VA, Sabba C, et al. Role of iodine, selenium and other micronutrients in thyroid function and disorders. Endocr Metab Immune Disord Drug Targets 2009; 18: 277-94.
- Mason MB. Vitamins, Trace minerals, and other micronutrients In: Goldman L, Ausiello D, editors. Cecil Medicine. 23rd Philadelphia, Pa; Saunders Elsevier; 2007. chap 237.
- National Committee for clinical laboratory standards (NCCLS). Evaluation of precision performance of clinical chemistry devices; approved guidelines. NCCLS document EPF-5-A.1999.
- Ayala AR, Danese MD, Landenson PW. When to treat mild hypothyroidism. Endocrinol Metab Clin N Am. 2000; 29: 399-415.
- Vanderpump MP, Tunbridge WM, French JM, et al. The incidence of thyroid disorder in community. A 20 yrs follow up of the wickham survey. Clin Endocrinol. 1995; 43: 55-68.