Title: IJV Thrombosis in a case of Tubercular Cervical Lymphadenopathy

Authors: Mittal Amol, Baral, Sonia, Thakur, Sanjiv Shamrao

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.68

Abstract

Background: A 44-year-old female came to tertiary care hospital with complaints of swelling present in neck region on left side along with discharging fluid since last 1month. The swelling was tender, fluctuant, non-pulsatile, non-reducible in nature. It was associated with local rise of temperature and associated with discharge. Patient received seven-day course of an antibiotic (Amoxycillin-clavulanic acid) at local place without relief. Patient was vitally stable with oxygen saturation of 98 percent on room air. USG showed well-defined, heterogeneous, predominantly hypo-echoic conglomerated lymph nodes in cervical region at level II largest measuring 3.4*3*4.2 cm with necrotic material within it. The visualized left Internal Juglar Vein showed echogenic material with absent colour flow suggestive of left side IJV thrombosis (Fig 1).

Methods & Results: Ultrasound-guided fine-needle aspiration cytology of the cervical node was performed, which showed caseous necrosis and epitheloid granuloma, with acid-fast bacilli being positive. Patient was started on Anti-tubercular drug after the diagnosis was made. Subsequently patient was started on LMWH for the underlying IJV thrombosis with the warfarin cover and PT-INR monitoring.

Discussion: IJV thrombosis is a serious entity with a potentially fatal outcome. Its complications could include pulmonary embolism and sepsis as well as intracranial propagation of the thrombus. The thrombogenic potential of tuberculosis is not well known however it has been postulated to be a hypercoagulable state that appears to develop secondary to the acute phase response. Knowledge about IJV thrombosis secondary to tubercular cervical lymphadenopathy among general surgeonsis quintessential as the presentation can easily be mistaken for neck abscess, treatment is not standardized and the incidence of occurrence is rare.

Keywords: Tuberculosis; IJV thrombosis; Cervical Lymphadenopathy; Case Report; Anti-coagulation.

References

  1. Gowrinath K, Nizami MI, Kumar BEP, Suneetha P, Kishor VH. Unusual complication of cervical tuberculous lymphadenopathy. Indian J Tuberc. 2011;58(1):35–7.
  2. Badawi M, Badawi MA, Alam J, Khan Z. A Rare Presentation of Mediastinal Lymphoma: Upper Airway Obstruction and Internal Jugular Vein Thrombosis. Ibnosina J Med Biomed Sci [Internet]. 2012 Apr 13 [cited 2018 Jan 2];4(2):60–2. Available from: http://journals.sfu.ca/ijmbs/index.php/ijmbs/article/view/246
  3. Sheikh MA, Topoulos AP, Deitcher SR. Isolated internal jugular vein thrombosis: risk factors and natural history. Vasc Med [Internet]. 2002 Aug 1 [cited 2018 Jan 2];7(3):177–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12553740
  4. Yang JYK, Chan AKC. Pediatric Thrombophilia. Pediatr Clin North Am [Internet]. 2013 Dec [cited 2018 Jan 2];60(6):1443–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24237981
  5. Gupta R, Brueton M, Fell J, Lyall H. An Afghan child with deep vein thrombosis. J R Soc Med [Internet]. Royal Society of Medicine Press; 2003 Jun [cited 2018 Jan 2];96(6):289–91. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12782695
  6. Gomber S, Khalil A, Vij JC, Bahl VK, Kapoor R, Saini L. Budd Chiari syndrome in a child with hepatic tuberculosis. Indian Heart J [Internet]. [cited 2018 Jan 2];38(3):226–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3557528
  7. Lang IM, Mackman N, Kriett JM, Moser KM, Schleef RR. Prothrombotic activation of pulmonary arterial endothelial cells in a patient with tuberculosis. Hum Pathol [Internet]. 1996 Apr [cited 2018 Jan 2];27(4):423–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8617488
  8. Gogna A, Pradhan GR, Sinha RS, Gupta B. Tuberculosis presenting as deep vein thrombosis. Postgrad Med J [Internet]. BMJ Publishing Group; 1999 Feb [cited 2018 Jan 2];75(880):104–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10448473
  9. Turken O, Kunter E, Sezer M, Solmazgul E, Cerrahoglu K, Bozkanat E, et al. Hemostatic changes in active pulmonary tuberculosis. Int J Tuberc Lung Dis [Internet]. 2002 Oct [cited 2018 Jan 2];6(10):927–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12365581
  10. Lindahl AK, Odegaard OR, Sandset PM, Harbitz TB. Coagulation inhibition and activation in pancreatic cancer. Changes during progress of disease. Cancer [Internet]. 1992 Oct 15 [cited 2018 Jan 2];70(8):2067–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1394036
  11. Ogawa T, Uchida H, Kusumoto Y, Mori Y, Yamamura Y, Hamada S. Increase in tumor necrosis factor alpha- and interleukin-6-secreting cells in peripheral blood mononuclear cells from subjects infected with Mycobacterium tuberculosis. Infect Immun [Internet]. 1991 Sep [cited 2018 Jan 2];59(9):3021–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1879927
  12. Erkoç R, Uzun K, Yuca K, Etlik Ö, Doğan E, Sayarlıoğlu H, et al. INTERNAL JUGULAR VEIN THROMBOSIS TWO DIFFERENT ETIOLOGIES. Eur J Gen Med [Internet]. 2005 [cited 2018 Jan 2];2(3):123–8. Available from: http://www.bioline.org.br/pdf?gm05026
  13. Tovi F, Fliss DM, Noyek AM. Septic internal jugular vein thrombosis. J Otolaryngol [Internet]. 1993 Dec [cited 2018 Jan 2];22(6):415–20. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8158736
  14. Cohen J, Persky M, Reede D. Internal jugular vein thrombosis. Laryngoscope [Internet]. 1985; Available from: http://onlinelibrary.wiley.com/doi/10.1288/00005537-198512000-00008/full
  15. Almog S, Martinowitz U, Halkin H, Bank HZ, Farfel Z. Complex interaction of rifampin and warfarin. South Med J [Internet]. 1988 Oct [cited 2018 Jan 2];81(10):1304–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3175736
  16. Heimark LD, Gibaldi M, Trager WF, O’Reilly RA, Goulart DA. The mechanism of the warfarin-rifampin drug interaction in humans. Clin Pharmacol Ther [Internet]. 1987 Oct [cited 2018 Jan 2];42(4):388–94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3665337.

Corresponding Author

Amol Mittal

Department of General Surgery, BJGMC & Sassoon General Hospital,

Pune-411001 Maharashtra India

+91-8007771705, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.