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Category: Volume 06 Issue 02 February 2018
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Title: Biochemical Investigation in Prediction of Acute Pancreatitis

Authors: Dr Ashima Badyal, Dr Pallavi Mahajan

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.36

Abstract

Acute pancreatitis is a common clinical presentation. Gall stone disease and alcohol consumption are most common etiologies. Detection of biliary etiology is important in order to provide definite management in the form of cholecystectomy to prevent attacks .Sensitivity for abdominal ultrasound to detect cholelithiasis is decreased to 67-87% in presence of acute pancreatitis. Difference in biochemical investigations of acute biliary and non biliary pancreatitis has been proposed to increase the suspicion of biliary etiology.

A Cross sectional study was conducted in the Department of Biochemistry, Government Medical College, Jammu, J&K, India, with a diagnosis of first episode of acute pancreatitis during a period of 3 months i.e. May 2017 to July 2017. Alanine Transaminase levels were found higher in biliary group but not statistically significant.  Meanwhile mean of serum amylase was found much higher in biliary group. Further investigations suggested that the biliary etiology of Acute Pancreatitis should be considered in female patients with deranged Lever Function Test and highly raised serum amylase level even if initial Abdominal Ultra Sound do not detect cholelithiasis. Negative for cholelithiasis in this subset of patient should not be accepted. Thus definite management of cholelithiasis may be based upon early derangement of biochemical investigations while Endoscopic Ultra Sound seems to be a non mandatory investigation to detect the biliary cause of Acute Pancreatitis.

Keywords: Acute Pancreatitis, Cholelithiaisis, Amylase.

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Corresponding Author

Dr Ashima Badyal

214 Av Shastri Nagar, Jammu, J&K, India- 180004