Title: Role of Immunohistochemistry in Diagnosis of Undifferentiated Malignant Tumours
Authors: Dr Praveen Singh Dhakar, Dr Jayanti Mehta, Dr Alka Mittal
DOI: https://dx.doi.org/10.18535/jmscr/v6i2.09
Abstract
Background: Immunohistochemistry provides a true identitiy for undifferentiated tumours. The accurate typing of malignant and benign tumours are important for prognostic and therapeutic purposes.
Aim: The present study is designed
- To identify the histogenesis of undifferentiated malignant tumours by immunohistochemical analysis.
- To take out spectrum of tumours diagnosed as undifferentiated malignant, poorly differentiated and small round cell on histology.
Materials & Methods: A total of 92 cases diagnosed as undifferentiated malignant tumours, poorly differentiated malignant tumours as well as small round cell tumours on histopathology in the Department of Pathology, SMSMC Jaipur from October 2015 to January 2017 were taken and immunohistochemistry was applied to reach the final diagnosis.
Results: Its was possible to arrive at final diagnosis in 89 (96.73%) cases with the help of immunohistochemistry. Majority of the cases were of Mesenchymal lineage, among them Ewing’s sarcoma/PNET was the most frequent diagnosis followed by Non Hodgkin’s lymphoma (DLBCL) in hematopoietic lineage
Conclusion: Immunohistochemistry is valuable adjunct to H & E staining in diagnosis of undifferentiated tumours. Accurate typing is prognostically and therapeutically important, for that a panel approach of carefully selected antibodies is always recommended.
Keywords: Immunohistochemistry, Undifferentiated Malignant tumours, Small round cell tumours.
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