Title: Histopathological spectrum of ovarian lesions in tertiary care institute of central India

Authors: Dr Ashok Panchonia, Dr Aksharaditya Shukla, Prof. Dr C.V. Kulkarni, Dr Harshul Patidar

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i1.185

Abstract

Introduction: The ovarian pathology is currently among the widest and most complex problems in modern gynecology mainly through ovarian tumours. Its mortality rate exceeds the combined mortality of both endometrium and cervical neoplasm. We studied clinical spectrum, associated findings and the diverse histomorphological patterns of ovarian lesions, thus offering a specific diagnosis which is of paramount clinical significance for both pathologist and gynecologist for better understanding of the disease and planning proper management of the patients.

Materials and Methods: Histomorphological evaluation in 214 cases of ovarian neoplastic and non-neoplastic lesions received for histopathological diagnosis in three years duration. Detailed clinical, radiological, operative and gross findings were noted and co-related with histopathological findings.

Result: Out of 214 cases 133 were non neoplastic, 47 were benign, 03 were borderline and 31 were malignant. Most of the patients (62%) were from reproductive age group. Among non neoplastic lesions, simple serous cyst was most common (36%) followed by corpus luteal cyst (25%) hemorrhagic cyst (13.5%) and other. Of neoplastic lesions 55 are of surface epithelial type (66%) and germ cell tumour constituting 24.7% followed by other. Abdominal pain (38.7%) is most common presenting symptom followed by abdominal distension (34.1%), menorrhagia (18.2%), dysmenorrhea, polymenorrhea, weight loss, sterility, urinary symptoms and mass per vagina. Right ovary is affected more than left. All lesions of size 03cm or less are non neoplastic, 24 out of 31 malignant cases are more than 10 cm in size.

Conclusion: Ovary is a frequent site for primary cancer and due to its complex structure, primary ovarian neoplasms are of diverse histological types. The diversity of neoplasms makes it mandatory to classify the tumours accurately as histopathological diagnosis combined with clinical staging will help in rendering prompt and appropriate treatment to the patient.

Keywords: Cyst, Neoplastic, Ovary, Tumor

References

  1. Univ. Dr. Brăila Mihai , Kamal Kamal Constantin, Clinical-Epidemiological, Imagistic, Histological And Immunohistochemical Study Of Ovarian Mucinous Tumours University Of Medicine And Pharmacy Craiova.
  2. Adelmen S, benson CD, hertzler JH, surgical lesion of the ovary in infancy & childhood, surggynecolobstate 1975, 141 : 219-222
  3. Clement PB. Non-neoplastic lesions of the ovary. In: Kurman RJ edt. Blaustein's pathology of the female genital tract. 5thedn, New York :Springer verlag; p.675-727.
  4. Scully RE,Clement PB, Young RH, Miscellaneous primary tumours, secondary tumours, and non-neoplastic lesions of ovary. In : Mills SE, Carter D, Greenson JK, Oberman HA, Renter V, Stoler MH edts. Sternberg's diagnostic surgical pathology, 4th edn. Philadelphia : Lippincott Williams and Wilkins; 2004.p.2617.
  5. Arab M, Khayamzadeh M, Mohit M, Hosseini M, Anbiaee R, Tabatabaeefar M, . Survival of ovarian cancer in Iran: 2000-2004. Asian Pac J Cancer Prev 2009;10(4):555-8.
  6. Eriksson L, Kjellgren O, von SB. Functional cyst or ovarian cancer: histopathological findings during 1 year of surgery. Gynecol Obstet Invest 1985;19 (3):155-9.
  7. MacKenna A, Fabres C, Alam V, Morales V. Clinical management of functional ovarian cysts: a prospective and randomized study. Hum Reprod 2000;15(12):2567-9.
  8. Stany MP, Hamilton CA. Benign disorders of the ovary. Obstet Gynecol Clin North Am 2008;35(2):271-84.
  9. Rathi V et al Study Of Histopathological Spectrum Of Ovarian Lesions, Vikram University,Ujjain,2005.
  10. Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: a study of 282 cases. J Indian Med Assoc 2002; 100: 420, 423-4, 447.
  11. Ahmad Z, Kayani N, Hasan SH, Muzaffar S, Gill MS. Histological pattern of ovarian neoplasm. J Pak Med Assoc 2000; 50: 416-9.
  12. Koonings PP, Campbell K, Mishell DR Jr, Grimes DA. Relative frequency of primary ovarian neoplasms: a10 year review. Obstet Gynaecol 1989; 74: 921-26
  13. Rafiq B, Kokab H, Rao SI. Ovarian tumours. Professional Med J 2005;12(4):397–403.
  14. Chakrabortti DK, Lee CMS. Epidemiological study ovarian neoplasms. J Obstet gynaecol India 1990; 40:582 -6.
  15. Malukani P & Gonsai RN ‘Histopathological Study Of Ovarian Lesions’ gujrat university 2014.
  16. Oumachigui, Narasimhan KL, Reddy KS, et al. A clinicopathologic study of ovarian tumours in children. J Obstet Gynecol. 1991;140:441–5.

Corresponding Author

Dr Aksharaditya Shukla MD Pathology

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile No.: 8982882884

Address: 131, Viceroy Park, E8 Extension Arera Colony, Near Tilak Nagar, Bhopal M.P. 462039

Designation: Ex Resident, Department of Pathology MGM Medical College and M.Y. Hospital Indore M.P