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Category: Volume 06 Issue 01 January 2018
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Title: Attenuation of Hemodynamic Response during Laryngoscopy and Endotracheal Intubation: Effect of Clonidine and Dexmedetomidine

Authors: Dr B.K.Panda, Dr Malaya Ku Patel, Dr Mahendra Ekka, Dr Rajeshwar Verma

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i1.166

Abstract

Background: Laryngoscopy and endotracheal intubation violate the patient’s protective airway reflexes and invariably cause hemodynamic changes associated with increased heart rate, increased blood pressure and occasional disturbance in cardiac rhythm.

Aim: The aim of the study was to find the efficacy of α2-adrenoceptors agonist in attenuating pressor response while securing airway during surgery.

Methods: Ninety patients of ASA physical status I and II, in the age group between 25and 50 years, of either sex, undergoing various elective abdominal surgeries under general anaesthesia were randomly allocated into three groups. Both clonidine and dexmedetomidine administered intravenously just before laryngoscopy and endotracheal intubation effectively attenuated the hemodynamic response by limiting the extent of rises in heart rate and blood pressure.

Result: Dexmedetomidine has been found to provide better hemodynamic stability than clonidine.

Keywords: Laryngoscopy, .Dexmedetomidine, clonidine.    

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Corresponding Author

Dr Malaya Ku Patel

VIMSAR, BURLA