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Category: Volume 06 Issue 01 January 2018
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Title: Association of Diabetic Retinopathy, Albuminuria and CKD in Patients with Type 2 Diabetes Mellitus
Authors: Dr Annapurna Kumar, Dr Ravish Vaishnav

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i1.145

Abstract

Background: Retinopathy and renal involvement are two of the major microvascular complications of diabetes mellitus. Recent reports challenge the traditional view of renal involvement progressing from increased glomerular filtation to progressively increasing levels of albuminuria that culminate in chronic kidney disease, and have found that retinopathy and albuminuria may not always co-exist. This study was undertaken to understand the relationship between retinopathy, albuminuria and chronic kidney disease in patients with type 2 diabetes mellitus.

Methods: One hundred patients with type 2 diabetes mellitus attending the diabetic clinic were evaluated for retinopathy and renal parameters that included a 24 urinary albumin excretion, serum creatinine and evidence of chronic kidney disease based on the estimated glomerular filtration rate.

Results: 67 patients were found to have retinopathy, out of which 12 (17.9 %) had no evidence of any abnormal renal parameters, 25 (37.3%) had only abnormal albuminuria (microalbuminuria or macralbuminuria), one (1.5 %) had evidence of CKD, and 29 (43.3 %) had both albuminuria and CKD. 16 patients with CKD did not have any evidence of retinopathy.

Conclusion: There was a statistically significant association between the presence and severity of retinopathy,   and abnormal urinary excretion of albumin.  A similar association between retinopathy and CKD was not seen.

Keywords: Diabetic retinopathy, Microalbuminuria, Macroalbuminuria, Normoalbuminuria, Chronic kidney disease, Estimated glomerular filtration rate.

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Corresponding Author

Dr Annapurna Kumar

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