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Category: Volume 06 Issue 01 January 2018
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Title: Cytomorphological Analysis of Synovial Fluid in a Tertiary Care Hospital

Authors: Shraddha Karn, T.B.Uma Devi, Erli Amel Ivan, Ramya.G

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i1.125

Abstract

Synovial fluid helps to distinguish between various inflammatory, non-inflammatory, traumatic, septic and crystal induced arthritis, to the extent that it is called as the liquid biopsy of the joints. Analysis of synovial fluid is a minimal invasive technique and is vital in diagnosis and management. Inconclusive cytology reports may result from inadequate sampling to lack of ancillary studies. 72 synovial fluid samples from November 2015 to May 2017 in cytology section of Pathology Department was included in tertiary care hospital the study. Along with the routine cytological study, biochemical parameters and crystal examination with clinical correlation was done. Total of 72 cases taken in which 48 and 16 cases were acute and chronic synovitis respectively .6 cases of gout and 2 cases of rheumatoid arthritis. All cases of gout in the study showed high ESR level, thick consistency, whitish appearance and needle shape crystals. The cases with acute synovitis showed aspirates of high cellularity. Gout shows high glucose level. Proteins level were high for acute synovitis and rheumatoid arthritis Synovial fluid cytology with other biochemical , microbiological and polarized microscopy for needle examination  with clinical correlation is important for detail study of synovial fluid analysis and management.

Keywords: FNAC, Synovial fluid, Macroscopic examination, Biochemical analysis, Crystal examination.

References

  1. Bibbo M, Wilbur DC. Comprehensive Cytopathology. 3rd Philadelphia: Elseiver Saunders; 2008
  2. Najeeb Q ,Aziz R ,Hamid S, Khan AH. An Analysis of Different Type of Arthritis with Joint Effusion research.International Journal of Biomedical Research 2015; 6(4):274-8                                                       
  3. Swan A,Amer H,Dieppe P,The Value of Synovial Fluid Assays in the Diagnosis of joint Disease; a literature survey,Extended Report. Ann Rheum Dis.2002 ;61:493-8.
  4. Muralidharan gopalan NG, Harikrishnam V, Subbaiah S ,Srinivasan C. Idiopathic eosinophilic synovitis of knee Joint with Peripheral Eosinophilia a rare case report, Journal of Clinical and Diagnostic Research. 2015;9(1):01-2
  5. Koss L G Melamed MR .Koss Diagnostic Cytology and its Histopathologic Bases 5th Philadelphia; Elsevier Saunders .2014
  6. Teloh .A Clinical Pathology of Synovial Fluid ,Annals of clinical and Laboratory Science.1975;5(4)282-7
  7. Courtrey .P, Doherty. M.Joint aspiration and injection .Clinical Rheumatology. 2005;19(3):345-69
  8. Najeeb Q ,Aziz R ,Hamid S, Khan AH .An Analysis of Different Type of Arthritis with Joint Effusion research. International Journal of Biomedical Research 2015; 6(4):274-8
  9. Sangeeta B Kulkarni et al., Role of synovial fluid analysis and synovial biopsy in joint diseases. Bombay Hospital Journal. Oct 2004; 46: No.04
  10. Saptarini N.M, Wibowo M.S, Gusdinar T Correlation study of age, disease duration, and erythrocyte sedimentation rate among the indonesian rheumatoid arthritis patients. International Journal of Pharmacy and Pharmaceutical Sciences , 2015; 7( 11):274-277

Corresponding Author

Dr Ramya. G

Department of Pathology, Sri Manakula Vinayagar Medical College and Hospital,

Kalitheerthalkuppam, Puducherry 605 107

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., 9787740891