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Category: Volume 06 Issue 01 January 2018
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Title: To Study Prevalence of Organisms Causing Neonatal Septicemia in NICU in A Tertiary Care Hospital of Jhalawar

Authors: R.K Mishra, Manish Pokra, Rajesh Bansal, Shilpi Hora, Jyoti Rana, Yogendra Kumar Tiwari

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i1.121

Abstract

Neonatal septicaemia is one of the leading causes of mortality and morbidity in developing countries like India. Incidence varies from country to country but it is much higher in developing countries than  in  developed nations. Reasons are not only related to good   prenatal, perinatal and post natal care and the efficient antibiotic policies in developed countries, but also to the high rate of home deliveries, often  overseen  by unskilled  attendants,  in  developing countries. Appropriate intervention requires an early aetiological diagnosis. Microbial aetiology of neonatal septicaemia is diverse. Several studies on neonatal sepsis have documented the diversity of bacteria. The present study reiterates the earlier findings and emphasizes the importance of periodic surveys of microbial flora encountered in particular neonatal settings to recognize the trend. The present study was conducted in Department of Microbiology and Immunology, Jhalawar Medical College, Jhalawar from March 2016 to March 2017. Clinically suspected 298 samples were included in this study.

References

  1. Mondal GP, Raghavan M, VishnuBhat B, Srinivasan S(1991) Neonatal Septicemia Among Inborn and Outborn Babies in a Referral Hospital. Indian J Pediatr 58: 529-33.
  2. Roy I, Jain A, Kumar M, Agarwal SK (2002) Bacteriology of neonatal septicemia in a tertiary care Hospital of Northern India. Indian J Med Microbiol 20: 156-9.
  3. Tallur SS, Kasturi AV, Nadgir SD, Krishna BVS (2000) Clinico-bacteriol-ogical sudy of neonatal septicemia in Hubli. Indian J Pediatr 67: 169-74.
  4. Sankar MJ, Agarwal R, Deorari AK and Paul V K.Sepsis in the newborn. Indian Journal of Pediatrics.2008; 75(3): 261-266.
  5. Vergnano S, Sharland M, Kazembe P, Mwansambo C, Heath PT. Neonatal sepsis: An international perspective. Arch dis child fetal neonatal ed.2005; 90(3): 220-224.
  6. Kumhar GD, Ramachandran VG, Gupta P.Bacteriological analysis of blood culture isolates from neonates in a tertiary care hospital in India: Journal health population & nutrition.2002; 20(4): 343-347.
  7. Wu JH, Chen CY, Tsao PN,  Hsieh WS, and Chou HS. “Neonatal sepsis: a 6-year analysis in a neonatal care unit in Taiwan,” Pediatrics and Neonatology, vol. 50, no. 3, pp. 88–95, 2009. View at Publisher View at Google Scholar · View at Scopus
  8. UNICEF, WHO, The World Bank, and The United Nations, Levels and Trends in Child Mortality, UNICEF, New York, NY, USA, 2011.
  9. Black RE, Cousens S, Johnson HL et al., “Global, regional, and national causes of child mortality in 2008: a systematic analysis,” The Lancet, vol. 375, no. 9730, pp. 1969–1987, 2010. View at PublisherView at Google Scholar · View at Scopus
  10. Stoll BJ, Hansen N,  Fanaroff AA et al., “Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants,” The New England Journal of Medicine, vol. 347, no. 4, pp. 240–247, 2002. View at Publisher View at Google Scholar ·  View at Scopus
  11. Ferreira RC, Mello RR, and  Silva KS, “Neonatal sepsis as a risk factor for neuro developmental changes in preterm infants with very low birth weight,” Jornal de Pediatria, vol. 90, no. 3, pp. 293–299, 2014. View at Publisher View at Google Scholar ·View at Scopus
  12. Dammann O, Kuban KCK, and Leviton A, “Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm,” Mental Retardation and Developmental Disabilities Research Reviews, vol. 8, no. 1, pp. 46–50, 2002.View at PublisherView at Google Scholar · View at Scopus
  13. Edwards MS and  Baker CJ, “Sepsis in the newborn,” in Krugman's Infectious Diseases of Children, Gershon AA,  Hotez PJ, and Katz SL, Eds., p. 545, Mosby, Philadelphia, Pa, USA, 2004.View at Google Scholar
  14. Nelson textbook of Paediatrics, 19th Philadelphia; Saunders publication, 2012. Thomson Press India Ltd page No.306-309
  15. Tripathi S and Malik GK. Neonatal Sepsis: past, present and future; a review article. Internet Journal of Medical Update 2010 July; 5(2):45-54.
  16. Sankar MJ, Agarwal R, Deorari AK, Paul VK. Sepsis in the Newborn. AIIMS- NICU protocols 2008. IJP 2008; 75: 261-266.
  17. Gerdes SJ, Polin R. “Early diagnosis and treatment of neonatal sepsis”. IJP 1998; 65: 63-78.
  18. Patel SJ and Saiman L. “Antibiotic resistance in neonatal intensive care unit pathogens: mechanisms, clinical impact, and prevention including antibiotic stewardship,” Clinics in Perinatology, vol. 37, no. 3, pp. 547–563, 2010. View at PublisherView at Google Scholar · View at Scopus
  19. Bhat RY, Lewis LES and Vandana KE. Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a centre in India. Italian Journal of Pediatrics 2011 37:32. http://www.ijponline.net/content/37/1/32.
  20. Venkataseshan S, Kumar P, Dutta S et al. Blood cultures confirmed bacterial sepsis in neonates in a north Indian tertiary care centre: changes over last decade. Jpn. J. Infect. Dis 2009, 62; 46-50.

Corresponding Author

Manish Pokra

PG 3rd Year Resident, Department of Microbiology, Jhalawar Medical College, Jhalawar