Title: CLOVE Syndrome- Case Report of a rare Congenital Disorder
Authors: Rajni Sharma, Sujaya Manvi
DOI: https://dx.doi.org/10.18535/jmscr/v6i1.53
Abstract
Congenital lipomatous overgrowth, vascular malformations and epidermal nevi (CLOVE) syndrome is a recently delineated rare congenital disorder that comprises of vascular malformations (typically truncal), dysregulated adipose tissue, scoliosis and enlarged bony structures (typically of the legs) without progressive or distorting bony overgrowth. This recent delineation distinguishes it from Proteus syndrome, a disorder that comprises localized, progressive, postnatal overgrowth with bony distortion, dysregulated adipose tissue, cerebriform connective tissue, linear epidermal nevus, hemimegalencephaly and other manifestations1.
References
- Harit D, Aggarwal A. CLOVE syndrome with nevus unis lateris: report of a case. Pediatr Dermatol 2010;27:311–2.
- Alomari AI. Comments on the diagnosis and Management of Cloves syndrome. Pediatric Dermatol 2011;28:215-6.
- Kurek K.C, Luks VL, Ayturk UM, Alomari AI, Fishman SJ, Spencer SA et al. Somatic mosaic activating mutations in PIK3CA cause CLOVES Syndrome. AMHG 2012;90:1108–15.
- Mirastschijski U, Altmann S, Lenz-Scharf O, Muschke P, Schneider W. Syndromes with focal overgrowth in infancy: Diagnostic approach and surgical treatment. J Plast Surg Hand Surg, 2012;46:45–4.
- Alomari AI, Chaudry G, Rodesch G, Burrows PE, Mulliken J.B, Smith ER et al. Complex spinal-paraspinal fast-flow lesions in CLOVES syndrome: analysis of clinical and imaging findings. AJNR Am J Neuroradiol 2011.
- Alomari AI, Thiex R, Mulliken JB. Hermann. Friedberg’s case report: an early description of CLOVES syndrome. Clin Genet 2010:78:342–7.