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Category: Volume 06 Issue 01 January 2018
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Title: Comparative Evaluation of Endoscopic Brush Cytology and Biopsy in the Diagnosis of Upper Gastrointestinal Neoplasm

Authors: Rajesh Kumar Bhola, Samira Kumar Behera, Debi Prasad Mishra, Manoj Kumar Patra, Atanu Kumar Bal, Swayamprava Pradhan

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i1.27

Abstract

A prospective study was carried out on 120 patients undergoing endoscopic evaluation to assess the diagnostic utility of endoscopic biopsy and brush cytology in the diagnosis of upper gastrointestinal neoplasm. The findings of brush cytology were compared with that of endoscopic biopsy and/or excision biopsy. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of brush cytology in diagnosing upper gastrointestinal malignancies are 85.7%, 98.4%, 98%, 88.7% & 92.5% respectively and for endoscopic biopsy the values are 89.3%, 98.4%, 98%, 91.3% & 94.2% respectively. Whereas when the brush cytology and biopsy findings were taken together the diagnostic value was significantly improved with 98%, 96.8%, 96.5%, 98.4% & 97.5% respectively. Hence brush cytology is a useful adjunct in the diagnosis of upper gastrointestinal neoplasm and should be considered as a routine method in combination with endoscopic biopsy. Combined use of endoscopic biopsy and brush cytology together increases the sensitivity, negative predictive value and accuracy of diagnosis of malignancy.

Keywords: Brush cytology, endoscopic biopsy, upper gastrointestinal neoplasm.

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Corresponding Author

Dr Rajesh Kumar Bhola

Assistant Professor, Department of Pathology, IMS & SUM Hospital, Sector 8, Kalinga Nagar,

Bhubaneswar, Odisha, India – 751003

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mob: +919776304199