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Category: Volume 05 Issue 12 December 2017
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Title: The Relationship between Lipid Profile and Hypertension

Authors: Virendra Kumar, Rajesh Kumar Khare

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i12.159

Abstract

Background: Hypertension and variations from the norm of lipid profile frequently coincide. Irregularities in serum lipid and lipoprotein levels are perceived major modifiable cardiovascular disease and basic hypertension hazard factors. The target of this investigation was to examine relationship between Lipid Profile and Hypertension.

Materials and Methods: Sixty recently diagnosed adult hypertensive patients and an equivalent number of age-and sex-coordinated controls without hypertension were continuously enlisted from the hospital in North India. Full history was taken, clinical examination was done and different laboratory examinations were carried for all people in the two groups which incorporates serum triglycerides (TG), total cholesterol(TC), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL).Height and weight were measured with the subject in light garments without shoes, and Body Mass Index (BMI) (Kg/m2) was calculated.

Result: The mean age was (47.6 ± 7.5) year; (48.7± 6.4) year for hypertensive and control people. The hypertensive patients had essentially higher weight record than controls. All the lipid parts TC, TGL, LDL, VLDL, HDL were higher in the hypertensive patients than those in the sound controls. Most extreme occurrence of hypertension was seen in the age group 40-49 years. The triglyceride level was fundamentally higher in the male than female hypertensives.

Conclusion: This investigation demonstrated that lipid variations are highly prevalent among newly diagnosed hypertensives. There are biologic interrelations between BP and blood lipids that may impact the systems whereby blood pressure is related with danger of coronary heart disease.

Keywords:  Blood pressure, Lipid profile, Hypertension.

References

  1. B. Kannel,W. P. Castelli, T. Gordon, and P. M. McNamara, “Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study,” Annals of Internal Medicine, vol. 74, no. 1, pp. 1–12, 1971.
  2. R. Williams, S. C. Hunt, P. N. Hopkins et al., “Familial dyslipidemic hypertension. Evidence from 58 Utah families for a syndrome present in approximately 12% of patients with essential hypertension,” Journal of the American Medical Association, vol. 259, no. 24, pp. 3579–3586, 1988
  3. Saha MS, Sana NK, and RanajitKS.Serum lipid profile of hypertensive patients in the northern region of Bangladesh . J bio sci2006 , 14: 93- 8.
  4. Lepirl FB, M’buyamba-Kabangu J.R, Kayembe KP, et al. Correlates of serum lipids and lipoproteins in Congolese patients with arterial hypertension. Cardiovasc J south Afr. 2005; 16: 249-55.
  5. Bravo EL: Metabolic factors and the sympathetic nervous system. Am J Hypertens 1989;2:339S-344S
  6. Reaven GM, Hoffman BB: Hypertension as a disease of carbohydrate and lipoprotein metabolism. Am J Med 1989; 87:2S-6S
  7. Thelle DS, F0rde OH, Try K, Lehmann EH: The Troms heart study: Methods and main results of the cross-sectional study. Acta Med Scand 1976;200:107-118
  8. Sacks FM, Dzau VJ: Adrenergic effects on plasma lipoprotein metabolism: Speculation on mechanisms of action. Am J Med 1986;80(suppl 2A):71-81
  9. Day JL, Metcalfe J, Simpson CN: Adrenergic mechanisms in control of plasma lipid concentrations. Br Med J 1982;284: 1145-1148
  10. Singh RB, Beegom R, Ghosh S, Niaz MA, Rastogi V. Epidemiological study of hypertension and its determinants in an urban population of North India. J Hum Hypertens 1997; 11: 679-685.
  11. Whelton PK. Epidemiology of hypertension. Lancet 1994; 344: 101-106.
  12. Youmbissi TJ, Djoumessi S, Nouedoui C. Profile lipidique d’un group d’hypertendus camerounais noir Africains. Medicine d’Afrique Noire 2001; 31: 114-118.
  13. Ahaneku JE, Nwosu MC, Ahaneku GI, Okugba PC. Utilisation of Clinical chemistry tests with special reference to lipid profile in disease management in a Nigeria setting. East Afr Med J 1999; 76:172-175.
  14. Mgonda YM, Ramaiya KL, Swai ABM, Mc-Larty DG, George KM, Alberti M. Insulin resistance and hypertension in non-obese Africans in Tanzania. Hypertension 1998; 31: 114-118.
  15. Jarikre AE, Dim DC, Ajuluchukwu JNA. Plasma lipid levels in Nigerian hypertensives: the gender factor. Nig Qtr J Hosp Med 1996; 6: 293-298. Kaare II.
  16. Dag S. Association between blood presure and serum lipids in a population-The Tromso Criculation 1991:83 (4): 1305-13.
  17. Kelishadi R, Alikhani S, Delavari A, Alaedini F, Safaie A, Hojatzadeh E. Obesity and associated lifestyle be­haviours in Iran: Findings from the national non-com­municable disease risk factor surveillance survey. Pub­lic Health Nutr. 2008; 11:246-51
  18. Dancy C, Lohnsoonthorn V, Williams MA. Risk of dys­lipidemia in relation to level of physical activity among Thai professional and office workers. Sutheast Asian J Trop Med Public Health. 2008; 39:932-41.

Corresponding Author

Dr Rajesh Kumar Khare

Assoc Prof, Department of General Medicine,

Integral Institute of Medical Science and Research Lucknow, UP, India