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Category: Volume 05 Issue 12 December 2017
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Title: Status of Lipid Profile and Uric Acid in Sudden Sensorineural Hearing Loss

Authors: Dr Sujata Panda, Dr Sumitra Bhoi, Dr D Saranya

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i12.109

Abstract

Background: Sudden Sensory Neural Hearing Loss (SSNHL) is loss of  30dB HL over three contiguous audiometric frequencies within 3 days and the incidence is 5-20 per 1,00,000 population occurring mostly among adults in fifties and sixties. The cause is idiopathic but recently been attributed to disturbance in cochlear microcirculation secondary to dyslipidaemia.

Aim and Objective: The aim of our study is to establish a relationship between sudden sensory neural hearing loss (SSNHL) and vascular risk factors like serum lipid and uric acid.

Material & Methods: This is a case control study of 40 cases of SSNHL of age group 26-65 years attending the outpatient Department (OPD) of E.N.T, VIMSAR, Burla between 1st September to 30th November, 2017. After patient history, physical examinations and audiological examination, blood parameters like lipid profile and uric acid level were analysed. Levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-CH), very low density lipoprotein (VLDL-CH), high density lipoprotein (HDL-CH) and uric acid (UA) of these patients then compared with an age and sex matched control group of 40 patients treated in the same OPD for E.N.T diseases other than hearing loss during the same period.

Result: Statistical analysis showed that there was significant difference between the means of lipid profile and uric acid of the patients and the control group.

Conclusion: This study indicates that metabolic disturbances of serum lipids and uric acid may be potential risk factors for SSNHL.

Keywords: Sudden sensory neural hearing loss(SSNHL), dyslipidaemia, uric acid.

References

  1. Society for Otorhinolaryngology-Head and Neck Surgery of Chinese Medical Association. Diagnosis criteria and treatment guideline for Sudden Sensorineural Hearing Loss. Chinese J of Otolaryngology- Head and Neck Surgery, 41 (2006), p. 325.
  2. Byl FM Jr(1984) Sudden hearing loss: 8years experience and suggested prognostic table. Laryngoscope 94:674-661 pmid:6325838.
  3. Nakashima T, Itoh A, Misawa H, Ohno Y (2000). Clinicoepidemiological features of sudden deafness diagnosed and treated at university hospitals in Japan. Otolaryngol Head Neck surg123:593-597, pmid: 11077347.
  4. Olzowy B,Osterkorn D, SuckfullM.The incidence of sensoneurinal sudden hearing loss is greater than previously presumed MMW Fortschr Med., 147 (2005), pp. 37-38.
  5. Chau JK, Lin JR, Atasband S, Irvine RA, Westerberg BD(2010) Systematic review of the evidence for the etiology of adult sudden sensory neural hearing loss. Laryn-goscope 120:1011-1021 pmid: 20422698
  6. Marcussi R, Sodi A,Giambene B, et al. Cardiovascular and thrombophilic risk factors for sudden hearing loss (J) Otology & Neurology  2002,23:309-311
  7. Cadoni G, Scipione S, Agostino S, et al. Coenzyme Q 10 and cardiovascular risk factor in idiopathic sudden sensorineural hearing loss patients [J]Otol Neurotol., 28 (2007), pp. 878-883.
  8. Cadoni G, Scorpecci A, Cianfrone F, Giannantonio S, Pakedetti G, Lippa S(2010), Serum fatty acids and cardiovascular risk factors in sudden sensorineural hearing loss. A case -control study. Ann otol Rhinol Laryngol 119:82-88 pmid:20336917.
  9. Rudak C, Langer C, Stoll W, Rust S, Walter M(2006) Vascular risk factors in sudden hearing loss. Thumb haemost 95: 454-461 pmid:16525573.
  10. Quaranta M, Rammunni A, Brscia P, D’Elia A, Ria R(2008) soluble intracellular adhesion molecule and soluble vascular cell adhesion molecule in sudden hearing loss. OtolNeurotol 29: 470-474 pmid :18401280.
  11. Hamed SA and EL-AttAr Am(2010) cochlear dysfunction in hyperuricemia: otoacoustic emission analysis. American J.otolaryngology- Head and neck medicine and surgery 31:154-61.
  12. Sadr SM, Namaganden SM, Moadares MM and Rafieim(2009) serum uric acid levels and its association with cardiovascular risk factors.Iranian J Publ Health vol.38 No1pp53-59.
  13. Natalia Idam Sumula, Abdul kadir, Eka Savitri. Relationship between hyperuri-cemia with auditory disorders based on otoacuostic emission. International J of science: Basic and Applied research (IJSBAR) (2016) vol 27, No: 2, pp 63-69.
  14. Suckfüll M, Thiery J, Schorn K, Kastenbauer E, Seidel D. Clinical utility of LDL-apheresis in the treatment of sudden hearing loss: a prospective, randomized study. Acta Otolaryngol. 1999;119(7): 763–766. doi: 10.1080/00016489950180397
  15. Narozny W,Kuczkowski J. Kot J.et al. Prognostic factors in sudden sensory neural hearing loss: our experience and a review of the Ann Otol Rhinol Laryngol 2006;115(7):553-558 (pubmed)
  16. Byl Fm. Sudden hearing loss: eight years experience and suggested prognostic table. Laryngoscope. 1984;94:647-661(pubmed)
  17. Maru YK, Jain N. Lipid profile studies in inner ear dysfunction. Indian J Otolaryngol Head Neck surg. 1994;3(1):17–20.
  18. Oiticica J, Bittar RSM. Metabolic disorders prevalence in sudden deafness. 2010;65(11):1149–1153. doi: 10.1590/S1807-59322010001100017.
  19. Y. Lu, B.S. Tong, J.M. Yang, et al. Relationship between disturbed microcirc-ulation and sudden deafness Chinese Journal of Otology[J]., 5 (2007), pp.45-48.
  20. Axelsson A, Lindgren F. Is there a relationship between hypercholester-olaemia and noise-induced hearing loss? Acta Otolaryngol. 1985;100(5–6):379–386. doi: 10.3109/00016488509126561.
  21. Sutbas A, Yetiser S, Satar B, Akcam T, Karahatay S, Saglam K. Low- cholesterol diet and antilipid therapy in managing tinnitus and hearing loss in patients with noise-induced hearing loss and hyperlipidaemia. Int Tinnitus J. 2007;13(2):143–149.(pubmed)
  22. Ullrich D, Aurbach G, Drobik C. A prospective study of hyperlipidaemia as a pathogenic factor in sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol. 1992;249(5):273–276. doi: 10.1007/BF00714491.
  23. Kazmierczak H, Doroszeweska G. Metabolic disorders in vertigo, tinnitus, and hearing loss. Int Tinnitus J. 2001;7(1):54–58.(PubMed)
  24. Rudack, C. Langer, W. Stoll, et al.Vascular risk factors in sudden hearingloss[J]ThrombHaemost., 95 (2006), pp. 454-461.
  25. P. Toth.Reverse cholesterol transport, high-density lipoprotein’s magnificentmile [J] Current Arteriosclerosis Reports., 5 (2003), pp. 386-393.
  26. Nofer, B. Kehrel, M. Fobker, et al.HDL and arteriosclerosis: beyond reverse cholesterol transport [J] Atherosclerosis. 161 (2002), pp. 1-16.
  27. Suckfüll M, Thiery J, Wimmer C, Mees K, Schorn K. Hypercholesteremia and hyperfibrinogenemia in sudden deafness. 1997;76(8):453. doi: 10.1055/s-2007-997460.
  28. Thakur JS, Mohindroo NK, Vasanthalakshmi MS, Kashyap N, et al. Auditory brainstem evoked responses in hyperlipidaemia: effect of various lipid fractions on auditory function. 2012;126(3):249–256. doi: 10.1017/S0022215111003094.
  29. G. Lv, S.L. Liang.The association betw-een coronary heart diseaseand uricacid [J] Chinese Journal of Cardiovascular Medicine., 3 (1998), pp. 288-289.
  30. U. Hink, N. Santanam, S. Dikalov, et al.Peroxidase properties ofextracellular superoxide dismutase: role of uric acid in modulating in vivo activity [J] Arterioscler Thromb Vasc Biol., 22 (2002), pp. 1402-1408.
  31. Thanh- van N. Nguyen MD, William E. Brownell. Contribution of membrane cholesterol to outer hair cell, lateral wall stiffness. Otolaryngology – Head and neck surg, 1998 Vol: 119issue: 1 page: 14-20. Doi:10.1016/50194-5998(98)70167-6.

Corresponding Author

Dr Sumitra Bhoi

Assistant Professor, Biochemistry, VIMSAR, Burla, Odisha, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Phone no: 919438271740