Title: Spectrum of Pulmonary Histopathological Lesions: A Study of 100 Autopsy Cases

Authors: Dr Puneet Garg, Dr Aradhna Sharma, Dr Ramesh Kumar Kundal

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i12.15

Abstract

Background: Present days air pollution, environmental inhalants and chemical cum toxic substances become uncontrollable worldwide. Autopsy is an important and most useful way to find out the condition of internal organs in which a thorough examination is performed on a body after death to evaluate disease or injury that may be present and to determine the cause and manner of a person’s death.

Material & Methods: The study is done on 100 lung specimens from autopsy cases received in the Govt Medical College, Department of pathology, Patiala. Gross findings and microscopic features were recorded. The tissue specimens were fixed and processed and Paraffin sectioning was done followed by Haematoxylin and Eosin staining. The sections were then examined.

Results: Out of 100 specimens of lungs from autopsy subjects, 84 (84%) were males and 16 (16%) were females. Terminal events were seen in 58 cases. Emphysematous lesions were seen in 23 cases out of which 18 were males and 5 females. Granulomatous (Tuberculosis) lesions were seen in 9 cases. Pneumonia was seen in 7 out of 100 cases. There was only one case of malignancy.

Conclusion: In our study, the most common findings were terminal events and emphysema and these were more common in males. So we should plan to prevent the causes and reduce the prevalence of these conditions by various preventable measures.

Keywords: granulomatous, autopsy, pneumonia, emphysema and tuberculosis.

References

  1. Selvambigai G., Amudhavalli S., Deepak Chakravarthi C. D., Ravi S. Histopatho-logical study of lung in autopsy cases: a prospective study:ijrms20163772:4816-19
  2. Chauhan G , Madhuri Agrawal, Nirali Thakkar , Bharti Parghi. Spectrum of histopathological lesions in lung autopsy, jrmds Vol. 3 Issue 2 2015:109-12
  3. Kumar Abbas, Aster, Robbins, Cotran. Pathologic basis of disease. South Asia Ed. Vol Elsevier: 2014.
  4. Tariq Mahmood Tahir, Fakeha Rehman, Sadia Anwar and Farrukh Kamal.Pattern of pulmonary morphological lesions seen at autopsy Biomedica Vol. 29 2013:64-68
  5. Rupali Ramrao Kurawar and Maya Suresh Vasaikar. Spectrum of histomorphological Changes in Lungs at Autopsy: A 5 Year Study, DOI: 10.21276/APALM.2017.961:A-106-112
  6. Roggli VL, Shelburne JD. Pneumoconiosis and minerals and vegetables. In: Dail DH, Hamman SP eds. Pulmonary Pathology. 2nd New York. Springer Verlag, 1994:868-9.
  7. YI Q, Zhang Z. The survival analysis analyses of 2738 patients with simple pneumoconiosis Occup Environ Med 1996; 53: 129-35.
  8. Cowie RL. The epidemiology of tuberculosis in gold miners with silicosis. Am J Respire Crt Care Med 1994; 150: 1460-2.
  9. KS Narayan Reddy, OP Murty. The essentials of Forensic Medicine and Toxicology, 33rd edition.JayPee Brothers: 2014.
  10. Beckett WS. Occupational respiratory diseases. NEJM 2000; 342: 406-13.
  11. Saleem N, Saleem M, Dil AS. Monitoring gaseous pollutants at Murree Highway. Pakistan J Health 1991; 28: 3-5.
  12. Parmeggiani L, ed. Encyclopedia of Occupational Health and Safety. 3rd Geneva: International Labo- ur Office. 1983: 95-102.
  13. Davies FG, Bassett WH, eds. Clay’s Handbook of Environmental Health. 14th ed. London: HK Levis and co Ltd, 1977: 524-84.
  14. Mishra V. Health effects of air pollution. Available online at www.populationenvironmentresearch.org/html.
  15. Gamble M. The Haematoxylins. In: Bancroft JD and Gamble M, eds. Theory and Practice of histological techniques. 6th, New York: Churchill Livingstone 2008;121-33.
  16. Rapheal SS, Hyde TA, Mellor LD eds. Lynch’s Medical Laboratory Technology. 4th Ed Philadelphia. W.B.Saunders, 1983;14-39.
  17. Manjit S. Bal, S. Sethi,Anil K. Suri, Vijay K. Bodal  Dr. G. Kaur Histopatho-ligical pattern in lung autopies JPAFMAT 2008; 8(2). ISSN 0972-5687:29-31
  18. Udayashankar SK, Shashikala P, Kavita GU, Histomorphogical Pattern of Lung in Medicolegal Autopsies, Index Copernicus Value 2013; 6.14
  19. Gareth D. H. Turner, Charatdao Bunthi,Chizoba B. Wonodi, Susan C. Morpeth, Catherine S. Molyneux,Sherif R. Zaki The Role of Postmortem Studies in Pneumonia Etiology Research, Clin Infect Dis. 2012;1: 54.
  20. Niazi S. Morphological study of Pulmonary Embolism in autopsy cases. [Thesis]. Lahore: University of the Punjab, 1989.

Corresponding Author

Dr Puneet Garg

Address: Dr Puneet Garg S/O Madan Lal Garg

Geeta Bhawan Street Jawahrkey Road, Mansa (Punjab) 151505

9780013811, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.