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Category: Volume 05 Issue 11 November 2017
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Title: Study of serum uric acid levels in diabetics and its association with metabolic syndrome and cardiovascular morbidity

Authors: Dr Anjaneya Prasad V, Dr Sai Krishna K, Dr Kiran Durga Prasad J, Dr Sowmya Devi U

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i11.224

Abstract

Introduction: The incidence of diabetes mellitus is increasing during past few decades due to lifestyle changes in both developing and developed countries. Uric acid being an atherogenic marker presumed to have a role metabolic syndrome, but its role as an independent risk factor for cardiovascular diseases is still a matter of controversy. Here this study aimed to assess serum uric acid levels in diabetics, its association with metabolic syndrome and cardiovascular morbidity.

Materials and Methods: 200 patients who attended to General Medicine department were included in the study out of which 140(cases) were diabetics and 60 were non diabetics (controls). Age, sex, FBS, PPBS, HBA1c,serum uricacid,ECG,2DEHO,BMI, Waist Hip Ratio(WHR) were estimated, written informed consent was taken from all patients.

Results: Mean age for cases & controls was 59.13, 56.97 respectively. Mean BMI for cases and controls was 24.93 & 21.8 respectively. Mean serum uric acids for cases & controls was 5.25 &0.98 respectively.WHR abnormality was seen in 66 out of 140cases, lipid abnormalities were seen in 36 out of 140 cases. Coronary artey disease was seen in 24 of 140 cases of which 8 had hyperuricemia most of them were females.

Conclusion: Uric acid was significantly elevated in diabetic population. Significant correlation was noticed between serum uric acid and BMI as well as WHR. Elevated uric acid levels were significantly noticed among those with hypertension, dyslipidemia, coronary artery disease and chronicity of the diabetes 

Keywords: Diabetes, Metabolic Syndrome, Serum Uric acid, Coronary Artery Disease.

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Corresponding Author

Dr. Sai Krishna Kolluru

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