Title: Significance of Adenosine Deaminase Levels in Diagnosis of Pleural Effusion
Authors: Dr Arjun Ramaswamy, Dr Prem Maurya, Dr Udaya Suresh, Dr CD Kulkarni, Dr Arif Ali
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.217
Abstract
The present study was carried out in 71 patients in a tertiary care center with an aim to study the correlation of results of ADA test and lymphocyte proportion with clinical / radiological findings and results of other relevant laboratory investigations. Diagnostic utility of pleural fluid ADA levels in the diagnosis of tubercular pleural effusion was also determined and values of ADA in patients with tubercular pleural effusion and non tubercular pleural effusion compared. Incidence of tubercular pleural effusion was more common in 21 to 40 years age group and among sex distribution males were commonly affected compared to females. Fever, cough and chest pain were common presentation among the cases in the study group. Elevated ADA levels were seen among the cases who had cough in the study group. Positive Mantoux test result had significantly elevated ADA levels among the cases in study group. Presence of chest pain among the cases in study group had raised ADA levels. Cardiomegaly and oedema among the cases in study group did not have significant association with levels of ADA in the study group. Presence of cavitatory lesions and infiltrations in the lung had significantly elevated ADA levels among the study group. LDH, Sugar, TLC and lymphocytic proportions were significantly correlated with ADA levels among the cases in study.
References
- Richard W Light.Disorders of the pleura, mediastinum, diaphragm and chest wall. In: Kasper, Braunwald, Fauci, Haucer, Lingo, Jameson, ed. Harrison's principles of Internl Medicine.16th Ed. Vol,2,New York: Mc Graw Hill: 2005; 1565-1568.
- Editorials: Tuberculous pleurisy and adenosine deaminase. thorax, 1995;50: 593-94.
- Reechaipichitkul W, Kawamatawong T, Teerajetgul, et al. Diagnostic role of pleural fluid adenosine deaminase in tuberculous pleural effusion.South east AAsian J Trop Med Public Health, 2001; 32:383-9.
- Sonone K K et al. Study of Adenosine Deaminase Levels in Patients of Pulmonary Tuberculosis with and Without Pleural Effusion. IOSR Journal of Dental and Medical Sciences.2014;13(1):30-37.
- Zay Soe, Wunna Hla Shwe, Soe Moe. A Study on Tuberculous Pleural Effusion. International Journal of Collaborative Research on Internal Medicine & Public Health.2010; 2(3):32-48.
- Basu A, Chakrabarti I, Ghosh N, Chakraborty S. A clinicopathological study of tuberculous pleural effusion in a tertiary care hospital. Ann Trop Med Public Health.2012; 5:168-72.
- Lee YC, Rogers JT, Rodriguez RM, Miller KD, Light RW. Adenosine deaminase levels in nontuberculous lymphocytic pleural effusions. Chest.2001;120(2):356-61.
- De Oliveira HG, Rossatto ER, Prolla JC. Pleural fluid adenosine deaminase and lymphocyte proportion: clinical usefulness in the diagnosis of tuberculosis. Cytopathology.1994;5(1):27-32.
- Tunn Ren Tay and Augustine Tee. Factors affecting pleural fluid adenosine deaminase level and the implication on the diagnosis of tuberculous pleural effusion:a retrospective cohort study. BMC Infectious Diseases.2013,13:546.