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Category: Volume 05 Issue 11 November 2017
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Title: Evaluation of Serum Testosterone Level in Men with Type 2 Diabetes Mellitus

Authors: Samarth Sangamesh, Dnyanesh N. Morkar

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i11.192

Abstract

Background: Levels of testosterone and presence of anemia in diabetic males has been in focus over the past decade. Correlation of the testosterone level with anemia in such patients can help in improved diagnosis and management of diabetic condition.

Aim: The present study was conducted to estimate the serum testosterone levels and correlate it with hematocrit levels in type 2 diabetes patients.

Methodology: A total of 150 men were selected and divided into diabetic (HbA1c ≥ 6.5 %; n = 75) and non-diabetic (HbA1c ≤ 6.5 %, n= 75) groups, after diagnosis for the case-control study conducted for a period of 1 year. Serum levels of creatinine, ferritin, and iron were evaluated along with blood sugar and hematocrit levels. Serum testosterone levels were analyzed by enzyme-linked immunosorbent assay. Pearson’s correlation test, Chi square test, and student t-test were used for statistical analysis.P<0.05 was considered statistically significant.

Results: Testosterone levels were significantly (P< 0.001) correlated with hematocrit levels, body mass index, blood sugar levels, fasting blood sugar levels and postprandial plasma sugar levels. Serum iron levels (82.80 ± 38.09 vs. 93.77 ± 26.7µg/dL; P = 0.043) were significantly reduced in the diabetic patients with low testosterone level (187.42 ± 145.01 vs.406.91 ± 135.55 ng/dL; P = 0.0001). In contrast, serum ferritin level was more in diabetic group (P = 0.0023).

Conclusion: Reduced testosterone level can be used to determine insulin resistance and anemia and therefore can be further assessed for its establishment as a marker for the same.

Keywords: Hematocrit, Anemia, HbA1c, blood sugar

References

  1. Chowdhary S, Ahmad M. Comparative Study of Serum Testosterone Levels in Male Patients of Type 2 Diabetes Mellites and Non Diabetics Presenting with Complaints of Sexual Dysfunction. J Med Sci Clin Res 2017;5(3):18910-18916.
  2. Rajfer J. Relationship between testosterone and erectile dysfunction. Rev Urol 2000;2(2):122.
  3. Dandona P, Dhindsa S. Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity. J Clin Endocrinol Metab 2011;96(9):2643-2651.
  4. Stanworth RD, Jones TH. Testosterone for the aging male; current evidence and recommended practice. Clin Interv Aging 2008;3(1):25.
  5. Coviello AD, Kaplan B, Lakshman KM, Chen T, Singh AB, Bhasin S. Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab 2008;93(3):914-919.
  6. Kapoor D, Aldred H, Clark S, Channer KS, Jones TH. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes. Diabetes Care 2007;30(4):911-917.
  7. Fukui M, Tanaka M, Hasegawa G, Yoshikawa T, Nakamura N. Association between serum bioavailable testosterone concentration and the ratio of glycated albumin to glycated hemoglobin in men with type 2 diabetes. Diabetes Care 2008;31(3):397-401.
  8. Devi S, Saxena J, Rastogi D, Goel A, Saha S. Effect of short-term physical exercise on serum total testosterone levels in young adults. Indian J Physiol Pharmacol 2014;58(2):178-181.
  9. Ferrucci L, Maggio M, Bandinelli S, Basaria S, Lauretani F, Ble A, et al. Low testosterone levels and the risk of anemia in older men and women. Arch Intern Med 2006;166(13):1380-1388.
  10. Khambatta S, Nguyen DL, Wittich CM, editors. 38-year-old woman with increasing fatigue and dyspnea. Mayo Clinic Proceedings 2010: Mayo Foundation.
  11. Sarkar M, Rajta PN, Khatana J. Anemia in Chronic obstructive pulmonary disease: Prevalence, pathogenesis, and potential impact. Lung India 2015;32(2):142-151.
  12. Miller JL. Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med 2013;3(7):a011866.
  13. Bachman E, Travison TG, Basaria S, Davda MN, Guo W, Li M, et al. Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point. J Gerontol A Biol Sci Med Sci 2013:glt154.
  14. Shalitin S, Carmi D, Weintrob N, Phillip M, Miskin H, Kornreich L, et al. Serum ferritin level as a predictor of impaired growth and puberty in thalassemia major patients. Eur J Haematol 2005;74(2):93-100.
  15. Chao KC, Chang CC, Chiou HY, Chang JS. Serum Ferritin Is Inversely Correlated with Testosterone in Boys and Young Male Adolescents: A Cross-Sectional Study in Taiwan. PLoS One 2015;10(12):e0144238.
  16. Hackett G, Cole N, Bhartia M, Kennedy D, Raju J, Wilkinson P. Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: the BLAST study. ‎J Sex Med 2014;11(3):840-856.
  17. Dhindsa S, Prabhakar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P. Frequent occurrence of hypogonad-otropic hypogonadism in type 2 diabetes. J Clin Endocrinol Metab 2004;89(11):5462-5468.
  18. Grossmann M, Thomas MC, Panagiotopoulos S, Sharpe K, Macisaac RJ, Clarke S, et al. Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab 2008;93(5):1834-1840.
  19. Al Hayek A, Ajlouni K, Khader Y, Jafal S, Khawaja N, Robert A. Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional study. J Family Community Med 2013;20(3):179.
  20. Kapoor D, Aldred H, Clark S, Channer KS, Jones TH. Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes Correlations with bioavailable testosterone and visceral adiposity. Diabetes Care 2007;30(4):911-917.
  21. Cheung KK, Luk AO, So WY, Ma RC, Kong AP, Chow FC, et al. Testosterone level in men with type 2 diabetes mellitus and related metabolic effects: A review of current evidence. J Diabetes Investig 2015;6(2):112-123.
  22. Saad F. The role of testosterone in type 2 diabetes and metabolic syndrome in men. Arq Bras Endocrinol Metabol 2009;53(8):901-907.
  23. Basu AK, Singhania P, Bandyopadhyay R, Biswas K, Santra S, Singh S, et al. Late onset hypogonadism in type 2 diabetic and nondiabetic male: a comparative study. J Indian Med Assoc 2012;110(8):573-575.
  24. Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson K-F, et al. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care 2005;28(7):1636-1642.
  25. Bebb RA. Testosterone deficiency: Practical guidelines for diagnosis and treatment. BC Med J 2011;53(9):474-479.
  26. Saboor Aftab SA, Kumar S, Barber TM. The role of obesity and type 2 diabetes mellitus in the development of male obesity-associated secondary hypogonadism. Clin Endocrinol 2013;78(3):330-337.

Corresponding Author

Dnyanesh N. Morkar

Department of Medicine, Jawaharlal Nehru Medical College,

Belagavi, Karnataka- 590010

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Tel: +919448231298