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Category: Volume 05 Issue 11 November 2017
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Title: Evaluation of Antihyperglycemic activity of aqueous extract of Carica papaya linn. leaves in Alloxan induced diabetic Albino rats

Authors: Ahmed. SK, Sampath.D, Chakrapani Cheekavolu, Sunil.M, Naveen Alasyam

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i11.187

Abstract

Background: Diabetes is everywhere a most common growing health concern in the world and is now emerging as an epidemic world over. Currently, more attention is being paid to the natural products study as potential antidiabetics. The study of plants that possess Antidiabetic activity may give a new idea in the treatment approaches of diabetes mellitus.

Objective:  The present study was aimed to evaluate the antihyperglycemic effect   of Aqueous extract of  Carica papaya linn. Leaves (AECPL) in alloxan‑ induced diabetic albino rats.

Methods: Albino rats weighing 150- 250 grams were grouped into 6 equal groups taking 6 rats in each. Group A served as control(normal), Group B as diabetic control, Group C, D & E was  receivedalloxan+ AECPL  suspension  at a doses  of  100,  200 & 400 mg/kg orally  respectively, Group F  was  givenalloxan + standard drug Glibenclamide (0.1mg/kg b.w.) suspension  for 21 days &  the AECPL  effect  on blood sugar  was measured at regular intervals. At the end of this research study blood samples were collected from all  rats for  biochemical estimation.

Results: The present study revealed that the AECPL has statistically significant (P < 0.05) and sustained Antihyperglycemic effect which is comparable with the hypoglycemic effect of standard drug Glibenclamide.

Conclusion: It is concluded  that  the  AECPL  has shown  significant  antihyperglycemic effect at  a  doses  of  100, 200 & 400 mg/kg. b.w. in  alloxan  induced  diabetic  albino  rats.

Keywords: AECPL, Glibenclamide, Antidiabetic, Aqueous extract, albino rats, blood sugar, glucometer, herbal remedy.

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Corresponding Author

Dr Chakrapani Cheekavolu

Department of Pharmacology, Kerala Medical College and Hospital,

Mangode, Palakkad, Kerala, India,

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