Title: Cord Blood Albumin as Predictor of Neonatal Hyperbilirubinemia
Authors: A Baby Praveena, R Ramanathan
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.185
Abstract
Background: Neonatal hyperbilirubinemia is most common abnormal physical finding during the first week of life. Albumin would aid in the transport of bilirubin to liver. Lower cord blood albumin would act as predictor of neonatal hyperbilirubenemia.
Methods: This was a prospective observational study carried out among 150 term and preterm babies. Their cord albumin level were estimated. Jaundice was determined by using yellowish discoloration of eyes and skin and Kramer score. Statistics employed include Chi-square test and receiver operator characteristic curve.
Results: Study participants enrolled into the study was 150. Cord albumin was not significantly associated with sex, mode of delivery, gestational age and birth weight but significantly associated with Kramer score and yellowish discoloration of eyes and skin. When albumin was compared against the occurrence of clinical jaundice, sensitivity was found to be 69.44%, specificity was 98.24%, positive predictive value was 92.59% and Negative predictive value 91.05. The receiver operator characteristic curve indicated that the area under the curve was 0.876.
Conclusion: Cord albumin value can be used as a predictor of neonatal jaundice in both term and pre term babies. Our study showed increased specificity than sensitivity which warrants further exploration.
Keywords: Cord blood albumin, Neonatal hyperbilirubinemia, sensitivity, specificity, predictive value.
References
- Cloherty J, CEichenwald E, Rstart A. No Title. In: Williams L, editor. Manual of neonatal care. 8th ed. a wolter kluver business; 2015. p. 337.
- Bhutani V, Johnson L, Sivieri E. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. paediatrics. 1999;103(1):6–14.
- subcommitee on Hyperbilirubinemia A. Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation. Pediatrics [Internet]. 2004;114(1):297–316. Available from: http://www.citeulike.org/group/11862/article/5941222
- Venkatamurthy M, Murali S, Mamatha S. a Comparison Study: Cord Serum Albumin Is Compared With Cord Serum Bilirubin As a Risk Indicator in Predicting Neonatal Jaundice. J Evol Med Dent Sci [Internet]. 2014;3(15):4017–22. Available from: http://www.jemds.com/data_pdf/1_murali sm.pdf
- Bunt JEH, Rietveld T, Schierbeek H, Wattimena JLD, Zimmermann LJI, van Goudoever JB. Albumin synthesis in preterm infants on the first day of life studied with [1-13C]leucine. Am J Physiol Gastrointest Liver Physiol [Internet]. 2007;292(4):1157–61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17234894
- Reshad M, Ravichander B, Raghuraman T. A study of cord blood albumin as a predictor of significant neonatal hyperbilirubinemia in term and preterm neonates. Int J Res Med Sci [Internet]. 2016;4(3):887–90. Available from: http://www.msjonline.org/?mno=208978
- R RR, Gd S. Cord Serum Albumin As A Tool to Predict Neonatal Hyperbilirubinemia. 2017;2016(3):3–7.
- kumar S, G A M, J A, Reddy S. Low Cord Serum Albumin is A Risk Indicator in Predicting Neonatal Jaundice. IOSR J Dent Med Sci [Internet]. 2016;15(10):76–8. Available from: http://iosrjournals.org/iosr-jdms/papers/Vol15-Issue 10/Version-1/O1510017678.pdf