Title: Coronary Artery Disease Severity Assessment Using Urinary Dipstick Albumin Test

Authors: Venkatram Murugesan, Nagarajan Kinathankaraiyan, Ashida S Thulaseedharan, Badrinath A Kuppuswamy

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i11.115

Abstract

Coronary artery disease refers to the gradual or sudden, reversible or irreversible obstruction to the heart’s blood supply due to the plaque build-up over several years or due to vasospasm. Albuminuria is one of the recently added risk factors for coronary artery disease. Consensus on albuminuria as an individual risk factor and whether it correlates with the severity of the disease is lacking. This study aims to correlate the severity of obstruction of coronary arteries with albuminuria in acute coronary syndrome patients. This study was done to correlate the severity of angiographically proven coronary artery disease with urinary dipstick albumin excretion in acute coronary syndrome patients. Acute coronary syndrome patients with more than 50% obstruction of one or more coronary arteries demonstrated by conventional coronary angiogram were included. Albuminuria by urinary dipstick method was analyzed. The data obtained was entered in the MS excel sheet and data analysis done using SPSS v24.0. In the study none of the subjects had history of Diabetes, Hypertension, Urinary tract infection and drug history. 65.5% of the patients had single vessel disease, 14.5% had double vessel disease and 20% had triple vessel disease. There was a statistically significant correlation between severity of coronary artery disease and albuminuria.

Key Words: Albuminuria, dipstick, coronary artery disease severity, acute coronary syndrome.

References

  1. Reddy KS. Cardiovascular disease in non-Western countries. New England Journal of Medicine. 2004 Jun 10;350(24):2438-40.
  2. Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries. Circulation. 1998 Feb 17;97(6):596-601.
  3. Karki P, Shrestha H, Shrestha NR. Albuminuria during acute coronary syndrome: A predictor for short term mortality and prognosis. Journal of Indian College of Cardiology. 2014 Sep 30;4(3):139-43.
  4. Weir MR. Microalbuminuria and cardiovascular disease. Clinical Journal of the American Society of Nephrology. 2007 May 1;2(3):581-90.
  5. Hoseini VN, Rasouli M. Microalbuminuria correlates with the prevalence and severity of coronary artery disease in non-diabetic patients. Cardiology journal. 2009;16(2): 142-5.
  6. Pradhep RS, Janakiram N, Benjamin VP, Natarajan S. A Study of Microalbuminuria in Coronary Artery Disease among Non-Diabetic Individuals. Int. J. Curr. Microbiol. App. Sci. 2017;6(1):344-61.
  7. Rein P, Saely CH, Vonbank A, Fraunberger P, Drexel H. Is albuminuria a myocardial infarction risk equivalent for atherothrom-botic events?. Atherosclerosis. 2015 May 31;240(1):21-5.
  8. Bouchi R, Babazono T, Yoshida N, Nyumura I, Toya K, Hayashi T, Hanai K, Tanaka N, Ishii A, Iwamoto Y. Association of albuminuria and reduced estimated glomerular filtration rate with incident stroke and coronary artery disease in patients with type 2 diabetes. Hypertension Research. 2010 Dec 1;33(12):1298-304.
  9. Escobedo J, Rana JS, Lombardero MS, Albert SG, Davis AM, Kennedy FP, Mooradian AD, Robertson DG, Srinivas VS, Gebhart SS, BARI 2D Study Group. Association between albuminuria and duration of diabetes and myocardial dysfunction and peripheral arterial disease among patients with stable coronary artery disease in the BARI 2D study. InMayo Clinic Proceedings 2010 Jan 31 (Vol. 85, No. 1, pp. 41-46). Elsevier.
  10. Maahs DM, Snell-Bergeon JK, Kinney GL, Wadwa RP, Garg S, Ogden LG, Rewers M. ACE-I/ARB treatment in type 1 diabetes patients with albuminuria is associated with lower odds of progression of coronary artery calcification. Journal of diabetes and its complications. 2007 Oct 31;21(5):273-9.

Corresponding Author

Venkatram Murugesan

Department of General Medicine,

Sri Manakula Vinayagar Medical College and Hospital,

Kalitheerthalkuppam, Puducherry 605 107

9042846842, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.