Title: Comparison of Clinicopathologic Features of Colonic Malignancies between Patients Aged below 50 and Patients aged above 50 Years
Authors: Joshinth Joseph, Abhilash Kumar, Manoj Thillai, Surendran Paramasivam, Naveen Alexander
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.05
Abstract
The incidence of colon cancer is low in India. More than 70% of colonic cancers occur in people aged 50 or older. However, colonic cancer appears to be increasing among younger patients. This study was done to compare and analyze the differences in clinical & pathological factors of colonic malignancies occurring in young patients (<50 years) and old patients (>50 years). The study showed male predominance within both groups (72% & 80%). Abdomen pain & altered bowel habits and abdomen pain with generalized weakness & anaemia were common presenting symptoms. Family history was an important predisposing factor in younger group (24%). Presentation as acute emergency was more common in younger group when compared to older group (36% & 20%). The younger group had more of left sided malignancy with poorly differentiated variety of carcinoma whereas it was evenly distributed in the older group. The time period between onset of symptoms and diagnosis was 2.4 months in younger group whereas 5.92 months in older group. Younger group tend to have more aggressive malignancy with poorer pathologic findings, and if detected early can have better overall survival rates.
Keywords: CarcinomaColon Malignancy Older Patients Younger.
References
- Mohandas, K. M.;Colorectal cancer in India: controversies, enigmas and primary prevention; Indian Journal of Gastroenterology 30.1 (2011): 3-6.
- Peedikayil, Musthafa Chalikandy, et al.; Colorectal cancer distribution in 220 Indian patients undergoing colonoscopy.; Indian Journal of Gastroenterology28.6 (2009): 212-215.
- Myers, Elizabeth A., et al.;Colorectal cancer in patients under 50 years of age: A retrospective analysis of two institutions’ experience.; World journal of gastroente-rology: WJG 19.34 (2013): 5651.
- Ben-Ishay, Offir, et al.”Diagnosis of colon cancer differs in younger versus older patients despite similar complaints”; The Israel Medical Association journal: IMAJ 15.6 (2013): 284-287.
- Chung, Y. F. A., et al.; “Young age is not a poor prognostic marker in colorectal cancer”; British journal of surgery 85.9 (1998): 1255-1259.
- Jarvinen, H. J., and M. J. Turunen. “Colorectal carcinoma before 40 years of age: prognosis and predisposing conditions”; Scandinavian journal of gastroenterology 19.5 (1984): 634-638.
- Giouleme, Olga, Michael D. Diamantidis, and Marios G. Katsaros. “Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms” World Journal of Gastroenterology: WJG 17.4 (2011): 444.
- Quah, H. M., et al. “Young age influences treatment but not outcome of colon cancer.” Annals of surgical oncology 14.10 (2007): 2759-2765.
- Howard, E. W., et al. “Colon and rectal cancer in the young adult.” The American surgeon 41.4 (1975): 260.
- O’Connell, Jessica B., et al. “Colorectal cancer in the young.” The American journal of surgery 187.3 (2004): 343-348.
- Isbister, William H. “Large-bowel cancer in the young: a national survival study.” Diseases of the Colon & Rectum 33.5 (1990): 363-366.