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Category: Volume 05 Issue 10 October 2017
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Title: Hematologic Analysis of Pancytopenia and Correlation with Bone Marrow Findings: Study in a Tertiary Care Centre

Authors: Kalyani Mahore, Hoogar M.B., Reeta Dhar, Evith Pereira, Vaidehee Naik

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i10.201

Abstract

Background: Pancytopenia is one of the most common haematological disorders, which is characterized by decrease in all the formed elements of blood. Pancytopenia occurs either due to certain primary conditions affecting the bone marrow or involvement of bone marrow secondarily by various systemic pathological process.

Objectives: The main objectives of the study are to evaluate the incidence and pattern of pancytopenia by analyzing the haematological data available during one year in the central laboratory of a tertiary care hospital in Navi Mumbai and to correlate the haematological findings with bone marrow findings.

Methods: The present prospective study, consists of an analysis of haematological data over a period of one year and analysing the incidence and pattern of pancytopenia and to correlate the haematological findings with bone marrow findings.

Results: In this study, 100 cases of Pancytopenia are diagnosed with an incidence of 0.47%. Bone marrow findings are available in only 15% cases of pancytopenia, and maximum incidence of pancytopenia, 5 cases (33.3%) is associated with chronic liver disease, followed by association with megaloblastic anaemia, 2 (13.3%) cases. In rest of the cases, definitive diagnosis of pancytopenia is not available, though the patients are being treated for various   clinical conditions.

Conclusion: The highest incidence of pancytopenia is found in age group of 40-70 years. Bone marrow findings confirmed the diagnosis in 15% cases, showing Dysmegakaryopoiesis maximum incidence of cases associated with erythroid hyperplasia with megaloblastoid changes and chronic liver disease accounted in 21 cases of pancytopenia.

Keywords: Pancytopenia, Megaloblastoid change, Dysmegakaryopoiesis

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Corresponding Author

Kalyani Mahore

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