Title: A Histopathological Study on Invasive Ductal Carcinoma Breast with Respect to ER/PR Status and Mast Cell Distribution
Authors: Dr Annu Sajeev, Dr Arun Antony, Dr Sarath Kumar
DOI: https://dx.doi.org/10.18535/jmscr/v5i10.172
Abstract
Introduction: When a carcinoma develops our immunity plays a major role in fighting against tumor cells. Mast cells which play a major role in our innate immunity are also found to get activated in a developing tumor. So far only few studies have been conducted on the role of mast cell in carcinoma breast which have shown the cytolytic activity of these on tumor cells and their relationship in response to hormone receptor status.
Aim: To study the histopathological characteristics of invasive ductal carcinoma breast. and mast cell count in them and their relationship with Estrogen & Progesterone receptor status.
Materials and Methods: We did a descriptive histopathological study on the specimens of modified radical mastectomy received in the Department of Pathology, Government Medical College, Thiruvananthapuram from 1st January 2012 to 2014. Histopathological characteristics of each case with respect to their ER/PR status was studied. Mast cell were stained using special stains and counted. Data was statistically analysed with SPSS software using Univariate analysis and chi square test to detect the significance of mast cell presence with receptor status in invasive ductal carcinoma breast.
Results: Out of total 150 cases the mast cells were present in 56 cases (37.3%) and were absent in 94 cases (62.7%). The relationship between presence of mast cells and estrogen and progesterone receptor positivity was found to be stastically insignificant as the p-value was more than 0.05. Thus there was no significant relationship between estrogen and progesterone receptor status with the presence of mast cells.
Conclusions: The present study showed that there is no significant relationship between presence of mast cells in peritumoral tissue and the hormonal status of the patient. So as per this study mast cell presence cannot be suggested as a definitive cheap easily assessable prognostic factor in carcinoma breast. Newer modalities for detection of new prognostic indicators can help in implementation of adjuvant therapies in a patient with ductal carcinoma breast.
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