Title: A Study on Red Cell Indices in Patients Having Heart Failure with Reduced Ejection Fraction

Authors: Dr Indhuja.K, Dr N.Chidambaram, Dr Periasamy, Dr Nanjilkumaran, Dr Gopathiraj.R

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i10.151

Abstract

Heart failure (HF) is a burgeoning problem worldwide with more than 20 million people affected. Search for a cost effective marker is ongoing to stratify the risks and outcome of heart failure. In this aspect this study aims to show that Red cell distribution width (RDW) when elevated is a predictor of all cause morbidity and low ejection fraction in a patient with left ventricular (LV) dysfunction.

Keywords: Heart failure, ejection fraction, red cell distribution width.

References

  1. Harrison textbook of Medicine 19th edition
  2. Pruett, A., Lee, A., Patterson, J., Schwartz, T., Glotzer, J., & Adams, K. (2014). Evolution of Biomarker Guided Therapy for Heart Failure: Current Concepts and Trial Evidence. Current Cardiology Reviews, 11(1), 80–89. https://doi.org/10. 2174/ 1573403X09666131117123525
  3. Laufer Perl, M., Havakuk, O., Finkelstein, A., Halkin, A., Revivo, M., Elbaz, M., Arbel, Y. (2016). High red blood cell distribution width is associated with the metabolic syndrome. Clinical Hemorheology and Microcirculation, 63(1), 35–43. https://doi.org/10.3233/CH-151978
  4. Kurtoğlu, E., Aktürk, E., Korkmaz, H., Sincer, İ., Yılmaz, M., Erdem, K., Özdemir, R. (2013). Elevated red blood cell distribution width in healthy smokers. Archives of the Turkish Society of Cardiology, 41(3), 199–206. https://doi.org/10.5543/tkda.2013. 42375
  5. Tertemiz, K. C., Ozgen Alpaydin, A., Sevinc, C., Ellidokuz, H., Acara, A. C., & Cimrin, A. (2016). Could “red cell distribution width” predict COPD severity? Revista Portuguesa de Pneumologia (English Edition), 22(4), 196–201. https://doi.org/10.1016/rppnen.2015.11.006
  6. Bozorgi, A., Nasab, E. M., Khoshnevis, M., Dogmehchi, E., Hamze, G., & Goodarzynejad, H. (2016). Red Cell Distribution Width and Severe Left Ventricular Dysfunction in Ischemic Heart Failure. Critical Pathways in Cardiology, 15(4), 174–178.
  7. Dai, Y., Konishi, H., Takagi, A., Miyauchi, K., & Daida, H. (2014). Red cell distribution width predicts short- and long-term outcomes of acute congestive heart failure more effectively than hemoglobin. Experimental and Therapeutic Medicine, 8(2), 600–606. https://doi.org/3892/etm.2014.1755
  8. Red Cell Distribution Width as a Novel Prognostic Marker in Heart Failure: Data from the CHARM Program and the Duke Databank. (2007). Journal of the American College of Cardiology, 50(1), 40–47. https://doi.org/10.1016/J.JACC.2007.02.067
  9. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005; 352:1011–23. [PubMed]
  10. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients. Scand J Clin Lab Invest. 2008;68:745–8. [PubMed]
  11. Isik T, Uyarel H, Tanboga IH, et al. Relation of red cell distribution width with the presence, severity, and complexity of coronary artery disease. Coron Artery Dis. 2012;23:51–6. [PubMed]
  12. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med. 2009;133:628–32. [PubMed]
  13. Semba RD, Patel KV, Ferrucci L, et al. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women’s Health and Aging Study I. Clin Nutr.  2010;29:600–4. [PubMed]
  14. Allen LA, Felker GM, Mehra MR, et al. Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. J Card Fail. 2010;16:230–8.  [PubMed]
  15. Anemia of chronic disease Guenter Weiss, M.D., and Lawrence T. Goodnough, M.D.N Engl J Med 2005; 352:1011-1023March 10, 2005DOI: 10.1056/NEJMra041809.

Corresponding Author

Dr Indhuja.K

General Medicine Postgraduate, Department of General Medicine,

Rajah Muthiah  Medical College and Hospital, 

Annamalai University, Annamalai Nagar - 608002