Title: Calcium dobesilate in Dermatology
Authors: Rajni Sharma, Sujaya Manvi
DOI: https://dx.doi.org/10.18535/jmscr/v5i10.42
Abstract
Phlebotonics are a heterogeneous class of drugs mainly used to treat chronic venous insufficiency and haemorrhoids. Most of these drugs are natural products extracted from plants (flavonoids, sapsonides, etc), but synthetic products are also used (calcium dobesilate). Calcium dobesilate is a synthetic venoactive drug thought to have antioxidant properties, reduce capillary permeability, increase venous tone and reduce inflammation. Calcium dobesilate (Cd) has been used successfully in chronic venous insufficiency, venous ulcers and stasis dermatitis, acute attacks of hemorrhoidal disease, diabetic retinopathy, gestational hypertension and myocardial infarction. Its antioxidant and angioprotective functions are responsible for these effects. It is safe, cheap and easily available therapeutic option for various disorders with gastrointestinal disturbances being the most common adverse effects.
Keyword: Phlebotonics, Phlebotropic drugs, Venoactive drugs, Calcium dobesilate (dobesilic acid, Cd), Chronic venous disease (CVD).
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