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Category: Volume 05 Issue 09 September 2017
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Title: Role of Glutathione S Transferases Polymorphism in type 2 diabetes mellitus, with and without micro vascular complications

Authors: Archana Mishra, Ajay Kumar, Sudheer Mehrotra, Rakesh Kr Shukla

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i9.173

Abstract

Background: Recent studies have revealed significant interethnic differences in frequencies of polymorphic GST genes and susceptibility to certain diseases in T2DM.

Aims and Objective: To study the original research work published over Glutathione S Transferases  Polymorphism, role in type 2 diabetes mellitus with and without micro vascular complications from year 2008-2017.

Method: A comprehensive web search was performed on Google research scholar, pubmed and HuGENet data base using the terms GSTM1 GSTT1 T2DM micro vascular case control year 2008-2017 and meta analysis done over the association of GSTM1 and GSTT1 polymorphism in T2DM with and without micro vascular complication (diabetic retinopathy, diabetic nephropathy and diabetic neuropathy). Total 383 T2DM with micro vascular complication, 315 T2DM without micro vascular complication and 424 healthy controls were included in the study from eligible 5 published papers.

Result: Result of Meta analysis show that GSTM1 & GSTT1 deletion singly or together associated with micro vascular complication.

Conclusion: This data has some limita­tions; it is restricted to five small studies. There is a need to con­solidate through more research in order to reduce the generalization error.

Keywords: GST, GSTM1, GSTT1, T2DM, Micro vascular complication, Diabetic Retinopathy, Diabetic Nephropathy and Diabetic Neuropathy, Diabetic mellitus type 2.

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Corresponding Author

Rakesh Kr Shukla

Tutor, Department of Anatomy, Dr RMLIMS, Lucknow, UP, INDIA

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