Objective: To evaluate the metabolic parameters in women with gestational diabetes mellitus after delivery in north Indian women.

Methods: This was a comparative study. A total of 50 patients were included in the study. Only those cases were included who had delivered in the study setting. On the first visit, detailed family history, personal history and dietary history were recorded.  Patients were followed up at 6 weeks, 6 months, 1 year, 2 year and 3 years after delivery.  At each visit BMI, glucose level, blood pressure and lipid levels were measured. 75 gm OGTT as defined by ADA for measuring glucose tolerance was used.

Results: Out of 50 patients, 33 (66%) were found to be dysglycemic. The Acanthosis nigricans was positive in 48.5% of Dysglycemia and in 5.9% of Normoglycemia. The BMI was found to be significantly (p<0.05) higher among the patients of Dysglycemia than Normoglycemia at all the time periods. The SBP and DBP was found to be significantly (p=0.0001) higher among the patients of Dysglycemia than Normoglycemia at all the time periods.The TG was found to be significantly (p=0.0001) higher among the patients of Dysglycemia than Normoglycemia at all the time periods. The HDL was also found to be significantly (p<0.01) lower among the patients of Dysglycemia than Normoglycemia at 6 weeks, 6 months and 1 year. LDL was significantly higher  among the patients of Dysglycemia than Normoglycemia at 1 year, 2 years and 3 years.

Conclusion: The end pregnancy is not the end of the story. In fact, it is the beginning of the new chapter for the prevention of diabetes and cardiovascular risk factors after delivery. Women with GDM should realize that they are sitting on an active volcano of metabolic syndrome which can erupt any time unless preventive measures are started at a war footing right from the every beginning.

Key words: Gestational diabetes,Dysglycemia, Normoglycemia.

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Nitin Ranjan Gupta

Assistant Professor, Department of Medicine

Integral Institute of Medical Sciences & Research, Lucknow

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