Title: Serum Uric Acid Levels in Patients with Type 2 Diabetes and Its Association with Diabetic Nephropathy in Patients Attending a Tertiary Care Centre in South Kerala
Authors: Dr Udayamma KP, Dr Ashish George
DOI: https://dx.doi.org/10.18535/jmscr/v5i9.135
Abstract
Introduction: Diabetc nephropathy constitutes the most common cause of end stage rena; disease worldwide. Inflammation and endothelial dysfunction appear to play a central role in the onset and progression of diabetic nephropathy. Recent evidences has emerged in the last decade to suggest that uric acid is an inflammatory factor and may play a role in endothelial dysfunction. Hence this study tries to evaluate any such correlation between diabetic nephropathy and serum uric acid.
Aim: To correlate Serum Uric Acid level with microvascular complications of Diabetes Mellitus.
Materials & Methods: it is a Cross sectional study of 1 year duration. The sample size was 625. Data analyzed using SPSS version 1.5.
Results: The mean uric acid value of the study population was 6.02 mg/dl . The mean uric acid level of those patients with nephropathy was 6.31 and that of patients without nephropathy was 5.68. There was no significant statistical association between elevated serum uric acid and with development of peripheral neuropathy. There was significant statistical association between elevated uric acid levels and development of retinopathy
Conclusions: There is significant correlation between the microvascular complications of diabetes mellitus and serum uric acid level except peripheral neuropathy.
Keywords: Diabetc nephropathy, serum uric acid, peripheral neuropathy, retinopathy.
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