Introduction: Diabetc nephropathy constitutes the most common cause of end stage rena; disease worldwide. Inflammation and endothelial dysfunction appear to play a central role in the onset and progression of diabetic nephropathy. Recent evidences has emerged in the last decade to suggest that uric acid is an inflammatory factor and may play a role in endothelial dysfunction. Hence this study tries to evaluate any such correlation between diabetic nephropathy and serum uric acid.

Aim: To correlate Serum Uric Acid level with microvascular complications of Diabetes Mellitus.

Materials & Methods: it is a Cross sectional study of 1 year duration.  The sample size was 625. Data analyzed using SPSS version 1.5.

Results: The mean uric acid value of the study population was 6.02 mg/dl . The mean uric acid level of those patients with nephropathy was 6.31 and that of patients without nephropathy was 5.68. There was no significant statistical association between elevated serum uric acid and with development of peripheral neuropathy. There was significant statistical association between elevated uric acid levels  and development of retinopathy

Conclusions: There is significant correlation between the microvascular complications of diabetes mellitus and serum uric acid level except peripheral neuropathy.

Keywords: Diabetc  nephropathy, serum uric acid, peripheral neuropathy, retinopathy.

1. Ahmed AM.History of diabetes mellitus. Saudi Med J  Apr;23(4):373-378
2. Global burden of diabetes. International Diabetes federation. Diabetic atlas fifth edition 2011, Brussels. Available athttp://www.idf.org/diabetesatlas
3. Joshi SR,Parikh RM India-diabetes capital of the world: now heading towards hypertension. J Assoc Physicians India. 2007 May; 55:323-4.
4. Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 diabetes: Indian scenario.Indian J Med Res. Mar 2007;125(3):217-230.
5. Reddy KS, Prabhakaran D, Chaturvedi V, et al. Methods for establishing a surveillance system for cardiovascular diseases in Indian industrial populations.Bull World Health Organ. Jun 2006;84(6):461-469.
6. Ritz E, Orth SR. Nephropathy in patients with type 2 diabetes mellitus. N Eng J M 1999; 341:1127-1133.
7. Adler AI, Stevens RJ, SE, et al: Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes study (UKPDS 64).Kidney Int 2003; 63:225-232.
8. Behradmanesh S, Horestani MK, Barad-aran A et al Association of serum uric acid with proteinuria in type 2 diabetic patients. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran;Journal of Reseach in Medical   2013;18 (1):44-6
9. Bonakdaran S, Hami M, Shakeri MT Hyperuricemia and albuminuria in patients with type 2 diabetes mellitus. Division of Endocrinology, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran published in Iran J Kidney Dis.2011;5(1):21-4.
10. Javad Kiani,Zahra Habibi,Ali Tajzie-hchi, Abbas Moghimbeigi, Arash Dehghan, and Homeyra Azizkhani. Association between serum uric acid level and diabetic peripheral neuropathy (A case control study). Caspian J Intern Med. 2014 Winter; 5(1): 17–21.
11. Jianfei Xia, Zonghua Wang, and Feifei Zhang. Association between Related Purine Metabolites and Diabetic Retinopathy in Type 2 Diabetic Patients. International Journal of Endocrinology Volume 2014, Article ID 651050, 9.
12. Jiji Inassi, Vijayalakshmy R Assistant Professor, Physiology, Govt. Medical College, Kozhikode, Kerala; Professor & HOD, Physiology Department, Academy of Medical Sciences, Pariyaram, Kerala,international journal of medical research, Vol 3│Issue 1│Jan –March 2013
13. Ficociello LH, Rosolowsky ET, Niewczas MA, Maselli NJ, Weinberg JM, Aschengrau A, et al. High-normal serum uric acid increases risk of early progressive renal function loss in type 2 diabetes: results of a 6-year follow-up.Diabetes Care. 2010 Jun;33(6):1337–43.

Dr Udayamma KP

Associate Professor, Dept of Medicine, Govt TD Medical College,

Vandanam PO, Alappuzha 688005

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