Details
Category: Volume 05 Issue 09 September 2017
Hits: 1312

Title: Malignant Phyllodes Tumour of Breast: Case Report and Review of Literature

Authors: Dr Narendra Nikam, Dr Alizaid Anwar, Dr Tejas Nikumbh, Dr Sandeep Darbastwar

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i9.105

Abstract

Phyllodes tumors are rare fibroepithelial breast tumors, which are sometimes difficult to preoperative diagnoses and have unpredictable clinical outcome. Malignant transformation of phyllodes is extremely rare. These tumors must be suspected in patients with rapid-growing breast nodules, with a history of local recurrences to avoid inappropriate management.

We report a case of a large phyllodes tumour of breast with malignant transformation in a 45 year old lady.

References

  1. Liang MI, Ramaswamy B, Patterson CC, McKelvey MT, Cordillo G, Nuovo GJ, Carson WE., III Giant breast tumors: surgical management of phyllodes tumors, potential for reconstructive surgery and review of literature. World Jr of Surgical Oncology. 2008;6:117. doi: 10.1186/1477-7819-6-117
  2. Khan SA, Badve S. Phyllodes tumors of breast. Curr Treat options Oncol.  2001;2:139–147. doi: 10.1007/s11864-001-0056-y.
  3. Tan P-H, Jayabaskar T, Chuah K-L, Lee H-Y, Tan Y, Hilmy M, et al. Phyllodes tumors of the breast the role of pathologic parameters. Am J Clin Pathol. 2005; 123:529–540. doi: 10.1309/U6DVBFM81MLJC1FN.
  4. Rowell MD, Perry RR, Jeng-Gwang H, Barranco SC. Phyllodes tumors. Am J Surg. 1993;165:376–79. doi: 10.1016/S0002-9610(05)80849-9.
  5. Erhan Y, Zekioglu O, Ersoy O, Tugan D, Aydede H, Sakarya A, Kapkaç M, Ozdemir N, Ozbal O, Erhan Y. p53 and Ki-67 expression as prognostic factors in cystosarcomaphyllodes. Breast J. 2002;8(1):38–44. doi: 10.1046/j.1524-4741.2002.08008.x
  6. Kim JH, Choi YD, Lee JS, Lee JH, Nam JH, Choi C et al. Borderline and malignant phyllodes tumors display similar promoter methylation profiles. Virchows Arch 2009;455:469-75.
  7. Bellocq JP, Magro G. Fibroepithelial tumors. In: Tavassoli FA, Devilee P, editors. World health organization classification of tumors: tumors of the breast and female genital organs. Lyon: IARC; 2003. p.99-103.
  8. Grabowski J, Salzsrein SL, Sadler GR, Blair SL. Malignatphylodes tumors: a review of 752 cases. Am Surg2007; 73:967-9.
  9. Goel NB, Knight TE, Pandey S, Riddick-Young M, Paredes ES, Trivedi A. Fibrous lesions of the breast: imaging-pathologic correlation. Radiographics2005;25:1547-59.
  10. Aguillar VLN, Bauab SP, Maranhão NM.  Mama: diagnósticoporimagem. Rio de Janeiro: Revinter; 2009.
  11. Uchman P, Samulak D, Wilczak M, Mich-alska MM, Mojs E, Sajdak S. Difficulties in diagnosing and treating phyllodes tumor of the breast – case report. Eur J GynaecolOncol2011;32:111-3.
  12. Jones A.M., Mitter R., Poulsom R. mRNA expression profiling of phyllodestumours of the breast: identification of genes important in the development of borderline and malignant phyllodestumours. J. Pathol. 2008;216(December (4)):408–417.
  13. Islam et al.The largest and neglected giant phyllodes tumor of the breast—A case report and literature review 10.1016/j.ijscr.2016.07.022
  14. Takenaka et al giant phyllodestmour case report ,Kurume me J .2011;58(2):67-72
  15. Tarunkumar et al , largest phyllodes-tumour a case report ,indian journal of oncology ,2011jun 2(2):141-144
  16. Sedigheh et allargephyllodestumour a case report ,middle east jounal of cancer 2013;4(4): 181-184.

Corresponding Author

Dr Alizaid Anwar