Title: Histopathological Analysis of Nephrectomy Specimens: Experience from A Tertiary Care Hospital
Authors: Dr Suma M T, Dr Usha Poothiode
DOI: https://dx.doi.org/10.18535/jmscr/v5i9.55
Abstract
Introduction: Renal Cell carcinoma is a malignancy of renal tubular epithelium and constitute 3% of all adult malignancies and constitute 80-90% of renal tumors. The morphological features including the histopathologic type, nuclear grade and extent of tumor involvement determine the aggressiveness and prognosis of Renal Cell Carcinoma.
Methods: 83 cases who underwent radicalor simple nephrectomy in a tertiary health care centerover a span of 4 years were included in the study. Their gross and microscopic features were studied.
Results: Renal cell carcinoma shows varying morphologic features in gross and histologic appearance. The predominant histologic variant is Clear cell variant and predominant nuclear grade of tumors is grade II.
Conclusion: Thorough evaluation of morphological parameters in Renal Cell Carcinoma is very essential for planning therapy and predicting the disease outcome.
Keywords: Kidney, Renal cell carcinoma, Clear cell carcinoma.
References
- Ozen H, Colowick A, Freiha FS, Incidently discovered solid renal masses:What are they ? Br J Urol.1993;72:274-6.
- Cohen HT, Mc Govern FJ: Renal-cell carci-noma. N Engl J Med2005;353:2477-2490
- Guinan P, Vogelzang NJ, Randazzo R, Sener S, Chmiel J, Fremgen A, Sylvester J: Renal pelvic cancer. A review of 611 patients treated in Illinois 1975–1985. Cancer Incidence and End Results Committee. Urology 1992; 40:393-399
- Störkel S Rumpelt HJ Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics.Pathol Res Pract.1986 May;181(2):125-43.
- Chang TS, Chang SK. 1980.PatientPlus articles, renal tumours, Egton Medical Information Systems DocID: 2722 Document Version: 22 DocRef: p 686.
- Hiroaki Masuda et al, Can symptoms predict the prognosis of RCC a multivariate analysis of 320 patients.
- Raica M Mederle O et al Urinary cytology in diagnosis of epithelial tumours of urotheliumDiagnCytopathol 1993,9;197-201
- Mahul B. Amin, M.D.; Mitual B.) Prognostic impact of adult renal epithelial neoplasms an experience of 405 cases. Am J SurgPathol 2002,26;281-291.
- A. Birnbaum et al:Renal cell carcinoma acorrelation of 100 tumours with ct findings – journal abdominal imaging volume 19-may 1999 pages 262-266.
- Renshaw AA, Granter SR, Fletcher JA: Renal cell carcinoma in hildren and young adults increased incidence of papillary architecture and unique subtypes Am J surg path 1999; 23;795-802.
- Leuschner I, Harms D and Schmidt D1991 Renal Cell Carcinoma in children: Histology, immunohistochemistry , and follow up 10 cases. Med PediatrOncol19 : 33-41.
- Bretheu Lechivallier E et al.Prognostic value of nuclear grade of renal cell carcinoma. Bretheau D, Lechevallier E, de Fromont M, Sault MC, Rampal M, Coulange C. Department of Urology, Salvator Hospital, Marseille, France.
- Nielsen k Ostri P 1988 Primary tumours of the renal pelvis : evaluation of clinical and pathological features in consecutive series of 10 years. J Urol 140: 19-21
- Maizals M, Simpson SB. Primitive ducts of renal dysplasia induced by culturing ureteric buds denuded of condensed renal blastema. Science.1983;219: 509 – 510
- EI Malik EM, Mmon SR,Ibrahim AL, AI Gizawi. Nephrectomy in adults:Asir Hospital Experience. Saudi J Kidney Dis Transpl 1997;8:423-7.