Title: Outcome of Autologous Bone Marrow Aspirate Concentrate (BMAC) Transplantation in Patient with Spinal Cord Injury: Our experiences
Authors: Das S, Islam MM, Mahbub H, Sarker AC, Dey S, Bhuiyan T
DOI: https://dx.doi.org/10.18535/jmscr/v5i8.185
Abstract
Introduction: Spinal cord injury (SCI) is a severe neurological disorder following trauma. Complete spinal cord injury ASIA Grade A with quadriplegia / paraplegia patients remains untreated and neglected in our country since long back. Now we planned effective strategy for the treatment of SCI by bone marrow derived mesenchymal stem cell transplantation has emerged as a viable therapeutic option with great potential for restoring neurological function following SCI.
Summary: From January 2016 to February 2017 a total of 10 SCI patient enrolled in our unit IV, Neurosurgery department, Dhaka medical college hospital, Dhaka, Bangladesh. All patients signed and given informed consent was taken prior to autologous bone marrow derived mesenchymal stem cell transplantation and bony decompression, fixation and fusion.
Result: Analysis of surgical outcome revealed significant improvement in motor, sensory and autonomic nerve function as assessed by the American spinal cord injury association impairement scale. 6 months after transplantation, a total of 10 patients, 9 patients demonstrated improvement. Among them 5 patients (50%) with Grade A SCI improved by one grade (i, e; Grade B), 3 patients (30%) with Grade A SCI improved by two grade (i, e; Grade C ), 1 patient (10%) with Grade A SCI improved by three grade( i, e;Grade D). In all patient, post surgical extensive physiotherapy and regular follow up given.
Keywords: Spinal cord injury (SCI),Bone marrow aspirate concentrate(BMAC),American Spinal Injury Association(ASIA).
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