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Category: Volume 05 Issue 08 August 2017
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Title: Antioxidant Status in HIV Positive Pregnant Women

Authors: Rajesh Bhanudas Rajekar, Hemakant Deshmukh, Vinayak Patil

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i8.172

Abstract

Aims and Objectives: Compare the level antioxidant in HIV positive pregnant, normal pregnant and non pregnant women, socioeconomic status and to determine oxidative stress levels in all study groups

  1. Glutathione (GSH) concentration
  2. Malondialdehyde (MDA) concentration
  3. Total Antioxidant Status (TAS)
  4. Glutathione Peroxidase (GPx)
  5. Super Oxide Dismutase (SOD)

Result and Conclusion: The activity of GR, GPx, SOD, MDA and total antioxidant in non pregnant, normal pregnant and HIV positive pregnant women. The activity in non pregnant women and normal pregnant women were 9.27 ±1.74, 47.30 ± 10.27,  1329.7  ± 111.8, 3.03  ± 0.49, 1.47 ±  0.18 and 4.37 ± 0.79, 27.17 ± 2.76, 944.9  ± 193.1, 4.50 ± 0.32, 1.19 ± 0.20 respectively. And the activity was 3.51 ± 1.15, 19.54 ± 2.51, 675.3 ± 125.9, 5.46 ± 0.55, and 0.88 ± 0.15 found in HIV pregnant women. It shows that the level of antioxidant in HIV pregnant women was significantly decreased but MDA level was slightly increased found compare to non pregnant and normal pregnant women.

On the basis of our result we concluded that the HIV positive pregnant women experience more free radical injury than those with HIV negative pregnant women. Due to oxidative stress, when highly induce it is involved in tissue damage. These mechanisms lead to the decrease of the antioxidant capacity of the body in HIV positive pregnant women.

Keywords: GR, GPx, SOD, MDA, HIV, AIDS, CD4, ROS, GSH and SES.

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Corresponding Author

Rajesh Bhanudas Rajekar

Assistant Professor Dept. of Biochemistry

Grant Government Medical College and JJ Group of Hospital Byculla Mumbai (MS)

Email Id:  This email address is being protected from spambots. You need JavaScript enabled to view it. Mob no. 07999678840.