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Category: Volume 05 Issue 08 August 2017
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Title: Evaluation of Effectiveness of Use of Oral Vit D Supplements in Documented Vit D Insufficient or Deficient Patients- A Study in North Bihar

Authors: Dr U.C.Jha, Dr Peyalee Sarkar

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i8.167

Abstract

Vitamin D is a group of fat soluble secosteroids responsible for a variety of physiological functions and mostly in respect to calcium homeostasis in the body. The major source of Vit D is from sunlight with a few other dietary sources. As Vit D is synthesised in the body it is being considered as a hormone more than a vitamin and has been found to have a role in prevention of various chronic illnesses like Diabetes, Cardiovascular disease.. The aim of the study was to determine the effectiveness of Oral Vit D supplements in patients with documented Vit D deficiency or insufficiency.

Method: Patients(20-70years, both gender) attending outdoors of Darbhanga Medical College and hospital over a period of 6 months(1 january 2017-31st june 2017) with nonspecific complaints of myalgia, joint pain fatigue were screened for serum Vit D levels and patients who were deficient or insufficient were given oral supplements and levels repeated at 6 and 12 weeks. The statistical significance of improvement was measured by paired student t test.

Results: Most of the patients demonstrated clinical and biochemical improvement after 6 weeks of therapy(p<0.01) and all patients achieved normal levels after 12 weeks of therapy(p<0.001). The gender basis evaluation of the Vit D deficiency turned out not in favour of women who were more deficient as compared to age matched male counterpart and people>60 years were more deficient.

Conclusion: A majority of Vit D deficient people may be asymptomatic. Therefore a keen eye and high index of suspicion is necessary providing a role for screening in patients with non specific complaints and being a routine in people with bone diseases. Oral supplementation is both cost effective and feasible with good patient compliance and hence is an effective method to replinish stores.

References

  1. Goswami r, Gupta et al Prevalence and significance of low 25-hydroxycobalamin D concentrations in healthy subjects in Delhi. Am J clin Nutr.2000;72:472-5
  2. Vitamin D Supplements in the Indian Market. Lhamo, Preeta Kaur Chugh, and C. D. Tripathi, Indian Journal of pharmaceutical sciences, Jan-Feb 2016
  3. Kishore A. Manek, Evaluation of efficacy of nano particle based Vit D formulation in correction of Vit D levels, International Journal of Research in orthopaedics, May-June 2017
  4. Gangadhar A. A novel, nano particle based liquid oral formulation of Vit D3 for managing Vitamin D deficiency: A survey of doctor’s preferances and practices in inida. The indian Practitioner. 2016
  5. Vitamin D deficiency: Pragmatic suggestions for prevention and treatment. Kalra S J Pak Med Asscociation 2017 July
  6. Vitamin D deficiency, oxidative stress and antioxidant status: only weak association seen in the absence of adva-nced age, obesity or pre-existing disease.
  7. Wang , Siu PM, Pang MY, Woo J, Collins AR, Benzie IFF, British Journal of Nutrition, July 2017
  8. Kennel KA, Drake MT et al Vit D Deficiency in adults: When to test and how to treat. Mayo CLinic Proc.2010;85 (8):752-8
  9. Basu TK, Donaldson D. Intestinal absorption in health and disease: micronutrients. Best Pract Res Clin Gastroenterol. 2003;17:957-79
  10. Mac Laughlin J, HOlick MF. Aging decreases the capacity of human skin to produce Vit D3. J Clin Investig
  11. Mithal A. Vitamin D Deficiency in India. Recommendation for prevention and treatment. Endocrine society of India Expert group. 2015, India: Elsevier
  12. Londhey V.Vitamin D Deficiency: Indian Scenario. J Assoc Physicians India. 2011;59
  13. Bothiraja C, Pawar A, Deshpande G. Ex vivo absorption study of a nanoparticle based novel drug delivery system of Vitamin D3 using everted intestinal sac technique. J Pharma Investigation 2016
  14. Mazahery H ,von hurst PrR. Factors affecting 25 hydroxylation D Concentration in response to Vitamin D Supplementation. 2015
  15. Vieth r. Vitamin D supplementation, 25 hydroxyvitamin D concentrations and safety. Am J Clin Nutr. 1999
  16. Hollick MF. Vitamin D deficiency.N Engl J Med 2007.

Corresponding Author

Dr Peyalee Sarkar

Resident, 2nd year, Darbhanga Medical College