Title: The Effect of Red Ginger Extract on Reduced Hormone Levels of Prostaglandin and Menstrual Pain Score in Adolescents with Dysmenorrhea
Authors: Friska Adiani, Hadi, Sri Rahayu, Noor Pramono, Melyana Nurul Widiyawati, Mardiyono
DOI: https://dx.doi.org/10.18535/jmscr/v5i8.158
Abstract
Background: Dysmenorrhea (pain during menstruation) causes adolescents to experience restrictions on daily activities such as decreased learning concentration and increased absenteeism. One way to handle dysmenorrhea is to use herbal remedies that are red ginger.
Objective: To determine the effect of the red ginger extract on prostaglandin hormone levels and menstrual pain score in the adolescent with dysmenorrhea.
Methods:The design of this study used quasi experiments with a pretest-posttest control group design. With a simple random sampling technique, 36 students were selected from the population, consisting of 18 students in the treatment group given red ginger extract with a dose of 1.5 grams/capsule, 3x1 daily and 18 students in the control group given mefenamic acid with a dose of 500 mg/capsule 3x1 daily during first and second menstrual period. Data analysis with paired t test and independent sample t test.
Results: red ginger extract and mefenamic acid significantly reduced prostaglandin hormone levels and menstrual pain scale, and by comparing two interventions, mefenamic acid may decrease prostaglandin hormone levels greater than red ginger extract, 177.35 pg/ml for Mefenamic acid and 124.55 pg/ml for red ginger.
Conclusion: red ginger extract can be used as an alternative intervention in treatment of adolescents with dysmenorrhea
Keywords: Dysmenorrhea, Red Ginger, Mefenamic acid, Prostaglandin hormone levels, Menstrual pain score.
References
- Lefebvre G, Pinsonneault O, Antao V, Black A, Burnett M, Feldman K, et al. Primary dysmenorrhea consensus guideline. SOGC clinical practice guideline. JOGC. 2005.
- Osayande, SA and Mehulic, S., Diagnosis and Initial Management of American Academy of Family Physicians. 2014; 89(5):341-346.
- Menurunkan intensitas nyeri menstruasi (dysmenorrhea) dengan terapi musik mozart. (internet). Available from: http://qittun.blogspot.com/2008/09/menurunkan-intensitas-nyeri-menstruasi.html.2008. [In Indonesia]
- George, S Nayana., Priyadarshini, S., & Shetty, S. Dysmenorrhoea Among Adolescent Girls Chaacteristics and Symptoms Experienced During Menstruation. Nitte University Journal of Health Science. 2014; 4(3): 45-52.
- Ozgoli, G., Goli, M. Moattar F. Comparison of effects of ginger, mefenamic acid and ibuprofen on pain in women with primary dysmenorrhea. 2009.
- Haghighi M, Khalvat A, Toliat T, Jallaei S. Comparing the effects of ginger (zingiber officinale) extract and ibuprofen on patients with osteoarthritis. Archives of Iranian Medicine. 2005
- Malhotra, S & Singh PA. Medicinal Properties of Ginger (Zingiber officinale Rosc). Natural Product Radiance Vol 2 (6). 2003.
- Jenabi E. The Effect of Ginger for relieving of Primary Dysmenorrhea. Journal of Pakistan Medical Association. 2013; 63: 8.
- Kashefi, F., Khajehei, M., Cher T, Mahb-, Alavinia, M.., Asili, J. Comparison of the effect of ginger and zinc sulfate on primary dysmenorrhea: a placebo-controlled randomized trial. Researchgate. 2012.
- Fathona D. Kandungan gingerol dan shogaol, intensitas kepedasan dan penerimaan panelis terhadap oleoresin jahe gajah (zingiber officinale var. Roscoe), jahe emprit (zingiber var amarum) dan jahe merah (zingiber officinale var rubrum). Fakultas teknologi pertanian IPB: Bogor. 2011.
- Tim Lentera. Khasiat dan manfaat jahe merah : si rimpang ajaib (Jakarta): Agromedia Pustaka; 2002.
- Hernani, Winarti. C. Kandungan bahan aktif jahe dan pemanfaatannya dalam bidang kesehatan (Bogor): Balai Penelitian Tanaman Obat dan Aromatik; . 2011.
- Kusumaningati RW. Analisis kandungan fenol total jahe secara in vitro. Fakultas kedokteran Universitas Indonesia: Jakarta. 2009
- Black CD, Herring MP, Hurley DJ, O’Connor PJ. Ginger (zingiber officinale) reduces muscle pain caused by eccentric exercise. The journal of pain. 2010
- Wresdiyati T, Astawan M, Adnyane IKM. Aktivitas anti inflamasi oleoresin jahe (zingiber officinale) pada ginjal tikus yang mengalami perlakuan stress. Jurnal teknologi dan industri pangan. 2003.