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Category: Volume 05 Issue 08 August 2017
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Title: Impact of Chemoradiation on Lung Function in Breast Cancer Survivours

Authors: Lone Mansoor Ul Haq, Wani Shahid Bashir, Refut Arah Banoo, Shah Saqib Ahmad, Sofi Mushtaq Ahmad, Teli Mohd Ashraf, Lone Mohd Maqbool

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i8.155

Abstract

Introduction: Both earlier diagnoses of the breast cancer and novel chemo radiation therapy strategies have resulted in a considerable improvement in breast cancer survival. This study was intended to assess the long term impact of these treatment modalities on pulmonary functions in survivors of carcinoma breast patients in Kashmir valley of Indian subcontinent.

Material and Methods: A prospective study in which breast cancer patients treated by combined modality treatment protocol with curative intent were taken for study. Patients with any co-morbid medical conditions like chronic lung disease, hypertension, asthma or drug intake for the same or any were not included in the study. Patients included in the study group had histopathological documentation of Carcinoma Breast, female sex, age greater than 18 years and geographical location of Kashmir Valley. Respiratory status assessment was done by pulmonary function test (spirometry) according to the guidelines prescribed in the American Thoracic Society (ATS) guidelines. The pulmonary function test values were compared with the patient’s predicted values and percentage change was calculated

Observations: While assessing pulmonary functions in the study group cases, revealed  slight restrictive ventilatory impairment in contrast to control group cases in the form of reduction in various spirometric parameters. Radiation and chemotherapy have synergistic effect on reduction in the spirometric parameters. The follow up time was less, need more follow up time.

Conclusion: Apart from the clear benefits of adjuvant chemo radiation, we should be aware of the potentially increased risk of pulmonary sequelae following specific radiotherapy regimens in long-term breast cancer survivors.

Keywords: breast cancer, long term toxicity, fibrosis, chemo radiation, pulmonary sequelae. 

 

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Corresponding Author

Wani Shahid Bashir

Senior Resident, Radiation Oncology SKIMS Srinagar