Title: A Study on the Prevalence of Non Alcoholic Fatty Liver Disease of Patients with Diabetes Mellitus

Authors: Atul Kumar, Mrityunjay Pratap Singh

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i8.146

Abstract

Objectives: Our study was to evaluate the prevalence and spectrum of disease of nonalcoholic fatty liver of patients with diabetes mellitus.

Methodology: A detail relevant history and assessment and relevant investigations was taken to all patients.  A complete laboratory investigation like Blood sugar (fasting and PP), Blood urea and Serum creatinine, Routine urine examination, Liver function tests, Lipid profile, HBsAg, Anti HCV, USG (Abdomen) were performed to all patients.

Results: Data was analyzed by using simple statistical methods with the help of MS-Office software.

Conclusions: Almost half of the cases of diabetes mellitus were affected with nonalcoholic fatty liver. Fatty liver disease may progress to steatohepatitis and cirrhosis. 

Keywords: Diabetes mellitus, non alcoholic, fatty liver.

References

  1. Angulo P.Nonalcoholic fatty liver disease. N Engl J Med 2002;346: 1221–1231.
  2. Clark Jand Diehl A. Hepatic steatosis and type 2 diabetes mellitus. Curr Diab Rep 2002;2: 210–215.
  3. Kumar KSand Malet PF. Nonalcoholic steatohepatitis. Mayo Clin Proc 75: 733–739,2000.
  4. Knobler H, Schattner A, Zhornicki T, Malnick SDH, Keter D, Sokolovskaya N, Lurie Y, and Bass DD.Fatty liver—an additional and treatable feature of the insulin resistance syndrome. Q J Med 1999;92: 73–79.
  5. Mavrogiannaki, I. N. Migdalis. Nonalcoholic Fatty Liver Disease, Diabetes Mellitus and Cardiovascular Disease: Newer Data. International Journal of Endocrinology Volume 2013 (2013),
  6. Harikrashna B. Bhattand Robert J. Smith. Fatty liver disease in diabetes mellitus. Hepatobiliary Surg Nutr. 2015 Apr; 4(2): 101–108.
  7. Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology2005;41:1313-21.
  8. Ryysy L, Hakkinen A-M, Goto T, Vehkavaara S, Westerbacka J, Halavarra J, and Yki-Jarvinen H.Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes  2000; 49: 749–758.
  9. Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A, Halavaara J, and Yki-Jarvinen H.Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum fatty acids independent of obesity in normal men. J Clin Endocrinol Metab  2002;87: 3023–3028.
  10. Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980; 55:434–438.
  11. Gábor Firneisz. Non-alcoholic fatty liver disease and type 2 diabetes mellitus: The liver disease of our age. World J Gastroenterol. 2014 Jul 21; 20(27): 9072–9089.

Corresponding Author

Dr Atul Kumar

Associate Professor, Department of Medicine,

Katihar Medical College, Katihar, Bihar, India

Ph: +91 8227040025, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.