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Category: Volume 05 Issue 08 August 2017
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Title: Role of microalbuminuria and hs-CRP in Helicobacter pylori infected type 2 diabetes mellitus in Eastern India

Authors: Syamal Modi, Krishanu Pal, Smriti Modi, Debabrata Datta, Pradip Kumar Agrawal

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i8.61

Abstract

Background: Helicobacter pylori (HP) infections are one of the few commonest worldwide which affects approximately 50% of the overall population. It is reported that high serum levels of C-reactive protein (CRP) is a novel cardiovascular risk factor that impairs endothelial function. H. Pylori infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP). Thus our study attempts to find the levels of microalbuminuria between H. pylori infected patients and non-infected patients in diabetes mellitus and establish its association with blood glucose levels. 

Materials and Methods: The case control study consists of 98 diabetic patients where 52 were clinically suspected case of H. Pylori infection and 46 without H. Pylori infection in medicine department. Serum hs CRP levels were determined with a high-sensitivity nephelometric method. Urinary albumin excretion was measured by nephelometric test for the measurement of microalbumin in urine. Three endoscopic biopsy samples were obtained from the antral mucosa of each patient. The first two biopsy samples were placed into 10% formol solution and dyed by Giemsa and hematoxylin-eosin while the third sample was given for rapid urease test and investigated for H. pylori.

Results: The presence of H. pylori infection was detected in 52 of 98 diabetic patients (53.06%). The ESR and hs-CRP levels were elevated in H. Pylori infected diabetes cases as compared to non-infected diabetics which were found statistically significant. The Microalbumin levels were higher in diabetic patients infected by H. pylori compared to non-infected patients (185.3 ± 90.5 vs 128.1 ± 42.6; p <0.001). However, a high positive correlation was observed between ESR with hs-CRP level (r = 0.825; P = <0.001) among H. Pylori infected diabetes subjects while no correlation was seen in non-infected diabetics (r = 0.279; P = 0.098). Conclusions: We have also observed an increase in hs-CRP and ESR levels in H.pylori infected diabetics which are also in confirmation with other fewer studies. Moreover, an association is observed between ESR and Hs-CRP in H. Pylori infected diabetics which suggest a plausible role in the pathogenesis and could be used as screening markers of the disease. hsCRP was higher among the infected individuals. The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.

Keywords: Helicobacter pylori, Type 2 diabetes mellitus, Microalbuminuria, hs-CRP, ESR.

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Corresponding Author

Mr Krishanu Pal

Tutor, Department of Microbiology,

ICARE Institute of Medical Sciences and Research, Haldia, West Bengal, India

Ph: +91- (M) 9007474520, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.