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Category: Volume 05 Issue 08 August 2017
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Title: Histomorphology of Lymphomas

Authors: Dr Hetal Joshi, Dr Jyoti P Sapre

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i8.30

Abstract

Context: Diagnosis of lymphoma constitutes a difficult task in context to subtyping. Accurate diagnosis is essential because the treatment options, responses to therapy and prognosis vary widely depending on the diagnosis. However to make a definitive diagnosis of a lymphoma based solely on the H & E light microscopy, findings may be exceedingly difficult because of frequent absence of distinguishing features. IHC represents a tool that can provide a clear distinction among the different types of lymphoma. The purpose of IHC is to categorize the patient in order to ensure appropriate and specific treatment, as well as to identify tumours at higher risk of recurrence and fatal outcomes.

Aims: To study histomorphology of different lymphomas and correlation of it with immunohistochemical findings.

Settings and Design: The present study is a retrospective as well as prospective study of lymphoma cases diagnosed based on routine histopathology as well as correlation of it with immunohistochemistry in surgical pathology section of the Central Diagnostic Laboratory, Shree Krishna Hospital, Karamsad from September 2010 to August 2015.

Materials and Methods: A detail clinical history, nature of specimen and other investigations were noted in the proforma. Macroscopic and microscopic findings or any incidental findings were documented in the final report.

Results: Total 47 cases of lymphoma were diagnosed in study period among them 42 cases were of B cell lymphoma and 7 cases were of T cell lymphoma. All B cell lymphoma were positive immunihistochemically for CD 20 and LCA. Out of 47 cases 25(53.19%) were of lymphoid origin and 22(46.81%) were of extralymphoid site.

Conclusion: From this study it was concluded that:

  • In all the cases diagnosis of hematoxyllin and eosin stained sections were correlated with immunohistochemical findings
  • Non Hodgkin's Lymphoma were most common than Hodgkin's lymphoma

Lymphnodes are the most common site of origin.

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Corresponding Author

Sujaya Manvi

Dermatologist, Civil Hospital Palampur, District Kangra, Himachal Pradesh

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