Title: Correlation of Tumour Size with Nuclear Grade, Stage and Extracapsular Extension in Renal Cell Carcinoma
Authors: Dr Suma M T, Dr Lovely Jose
DOI: https://dx.doi.org/10.18535/jmscr/v5i8.01
Abstract
Introduction: Renal cell carcinoma is malignancy of renal tubular epithelium with poor prognosis. We evaluated the association between size of tumor with nuclear grade, stage and extra capsular extension in Renal cell carcinoma as these are the most important parameters in the prognosis
Materials and Method: 30 nephrectomy specimens with a histopathological diagnosis of Renal cell carcinoma were included in the study. The size, stage, integrity of capsule and nuclear grade were assessed and correlated. Study was approved by the institutional ethical committee. Pearson correlation coefficient was doneusing SPSS program for data analysis.
Result: Large tumors showed extra capsular extension and higher nuclear grade with statistically significant correlation (p = 0.04) No significant correlation observed between size of tumor and stage.
Conclusion: Renal cell carcinoma with a large tumor size has higher grade disease and poor prognosis.
Keywords: Nephrectomy, Renal cell carcinoma, Fuhrman nuclear grade
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