Title: Aluminium Phophide Poisonoing: Can Acidosis Predict Mortality? A Study in North Bihar
Authors: Dr S.C.Jha, Abhinandya Mukhopadhyay, Dr R.K. Das, Dr B.K.Singh
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.256
Abstract
Aluminium phosphide poisoning has emerged as a major problem in rural India. No specific antidote is available. This study was conducted to evaluate relation between metabolic acidosis and outcome in terms of mortality.
Materials and Methods: An observational study was done on patients admitted with ALP (Aluminium phosphide) poisoning in DMCH, Bihar. Diagnosis was done clinically and biochemically. Clinical variables and outcomes were recorded and statistically analysed using appropriate test.
Results: Metabolic acidosis was significantly associated with mortality and higher duration of hospital stay.
References
- Anand R, Binukumar BK, Gill KD (2011) Aluminum phosphide poisoning: an unsolved riddle. J Appl Toxicol 31(6): 499-505
- Chugh SN (1992) Aluminium phosphide poisoning: Present status and management. J Assoc Physicians India 40: 401-405.
- Chugh SN, Sant Ram, Chugh K, Malhotra KC. Spot diagnosis of aluminium phosphide ingestion – an Application of a simple test. AAssor Physician Ind 1989: 37: 219-220.
- Goel A, Aggarwal P. Pesticide poisoning. Natl Med J India. 2007;20:182–91. .
- Gupta S, Ahlawat SK. Aluminum phosphide poisoning — A review. J Toxicol Clin Toxicol 1995;33:19-24
- Hossein Sanaei-Zadeh. Acute aluminium phosphide poisoning: Can we predict survival? Indian J Anaesth. 2012 Mar-Apr; 56(2): 207–208.
- Misra UK, Tripathi AK, Pandey R, Bhargwa B. Acute phosphine poisoning following injestion of aluminium phosphide.Hum Toxicol. 1988;7:343–5
- Nath NS, Bhattacharya I, Tuck AG, Schlipalius DI, Ebert PR (2011) Mechanisms of phosphine toxicity. Journal of Toxicology
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K (2006) Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila) 44(2): 155-158
- Singh S, Singh D, Wig N, Jit I, Sharma BK. Aluminum phosphide ingestion - a clinico-pathologic study. J Toxicol Clin Toxicol 1996;34(6):703-6.
- Siwach SB. 1997. Recent trends in the management of acute aluminium phosphide poisoning. Post Graduate Medicine. 11; 411 – 413.
- World Health Organization. T he World Health Report 2002: Reducing Risks, Promoting Healthy Life. Geneva: WHO; 2002
- Shadnia S,Sasania G, Allami p,Hosseini A,Ranjbar A,Amini-Shirazi N,Abdollahi M:A retrospective 7 years study of aluminium phosphide in Tehran: Oppurtunities for prevention. Human Experimental Toxicology.2009 April, 28(4):209-213.